PMID: 6963285Sep 1, 1982Paper

Effect of Chinese and western antimicrobial agents on selected oral bacteria

Journal of Dental Research
T F TsaoA K Horikoshi

Abstract

The susceptibility of selected oral bacteria, including suspected periodontopathogens, to a commonly employed Chinese herbal medicine Huang-chin (HC, Scutellaria baicalensis) was tested in vitro. The minimum inhibitory concentration (MIC) and minimum bactericidal concentrations (MBC) were determined. HC was also compared with tetracycline, alexidine, and stannous fluoride. HC decoction, at a concentration of 2%, was bacteriostatic in eight of 11 bacteria tested, but a concentration of 3.13% or greater was required for bactericidal effect. Among the tested bacteria, Bacteroides melaninogenicus ss intermedius was the most sensitive (MIC = 1.57%, MBC = 2%); Actinomyces viscosus was the least sensitive (MIC = 6.25%, MBC = 12.5%). Tetracycline, alexidine, and SnF2 were bactericidal in vitro in all bacteria tested at concentrations lower than those used clinically.

References

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Citations

Apr 12, 2008·Journal of Natural Medicines·Toshiaki MakinoHajime Mizukami
Mar 1, 1986·Journal of Ethnopharmacology·S G Franzblau, C Cross
Oct 21, 1998·International Dental Journal·C F Cao, X P Sun
Dec 1, 1987·Antimicrobial Agents and Chemotherapy·P W CaufieldN K Childers
Oct 24, 2007·Journal of Applied Microbiology·T P T CushnieA J Lamb
Sep 9, 2011·The Journal of Pharmacy and Pharmacology·Nilufar Z MamadalievaMichael Wink
Dec 3, 2011·Periodontology 2000·Elizabeth K Kaye
Dec 3, 2005·International Journal of Antimicrobial Agents·T P Tim Cushnie, Andrew J Lamb
Feb 13, 2018·Journal of Natural Medicines·Chang LiuZheng-Tao Wang
Mar 31, 2019·Dentistry Journal·Mesfin YimamQi Jia
May 19, 2001·Oral Microbiology and Immunology·J V EmbletonM Wilson
Aug 21, 2012·The Journal of Clinical Pediatric Dentistry·Y RamakrishnaA K Munshi
Jun 9, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Gururaj C AithalSanjay Garg

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