Effect of chloramphenicol on early mRNA synthesis in bacteriophage lambda.

Biochimica Et Biophysica Acta
Y Takeda

Abstract

The N gene product induces lambda-delayed early mRNA synthesis. This transcription was sensitive to chloramphenicol at the very early stage of phage development, but became resistant within 2-4 min after infection. However, the same transcription was sensitive to the antibiotic throughout phage development if lambda tof- mutant was used as the infecting phage. The results suggest involvement of the tof gene in lambda early transcription; the tof product may act as a stabilizer of the N gene function.

References

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Citations

Jun 1, 1981·Journal of Virology·J Finnegan, J B Egan
Sep 12, 1975·Biochimica Et Biophysica Acta·Y Takeda, M Kuwano
Aug 1, 1979·Journal of Bacteriology·T Hashimoto-Gotoh, J Inselburg
Dec 5, 1982·Journal of Molecular Biology·F BoschelliY Takeda

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