Effect of cholesterol and ergosterol on the compressibility and volume fluctuations of phospholipid-sterol bilayers in the critical point region: a molecular acoustic and calorimetric study

Biophysical Journal
Roland KrivanekRoland Winter

Abstract

Although sterol-phospholipid interactions have been of interest for many years now, a complete thermodynamic profile of these systems is still missing. To contribute to a better understanding of the thermodynamic functions of these systems, we determined isothermal compressibility coefficient data for dipalmitoylphosphocholine (DPPC) and DPPC-containing cholesterol and ergosterol vesicles by means of molecular acoustics (ultrasound velocimetry and densimetry) and differential scanning and pressure perturbation calorimetric techniques. A particular focus was on the influence of the differential structural properties of the two sterols on the thermodynamic properties of lipid bilayers, and on the nature of the critical point region of phospholipid-sterol systems by determining thermodynamic fluctuation parameters. Contrary to significant changes in conformational and dynamical properties of the DPPC-sterol membranes, no marked differences were found in the various thermodynamic properties studied, including the adiabatic (beta(S)(lipid)) and isothermal (beta(T)(lipid)) compressibility, as well as the volume fluctuations. Differences in beta(T)(lipid) and beta(S)(lipid) become dramatic in the gel-fluid transition region only, due ...Continue Reading

References

Oct 26, 1976·Biochimica Et Biophysica Acta·R A Demel, B De Kruyff
Jan 30, 1991·Biochimica Et Biophysica Acta·R C MacDonaldL R Hu
Jan 1, 1989·Journal of Biochemical and Biophysical Methods·W W Van OsdolM L Johnson
Nov 27, 1987·Biochimica Et Biophysica Acta·J H IpsenM J Zuckermann
Dec 9, 1985·Biochimica Et Biophysica Acta·P L Yeagle
Jan 1, 1984·Progress in Biophysics and Molecular Biology·A Cooper
Oct 14, 1980·Biochemistry·D L MelchiorJ M Steim
Jun 14, 1982·Biochimica Et Biophysica Acta·S Mitaku, T Date
Sep 6, 1994·Chemistry and Physics of Lipids·O G Mouritsen, K Jørgensen
Nov 7, 2000·Biochimica Et Biophysica Acta·J F Nagle, S Tristram-Nagle
Dec 26, 2001·Biophysical Journal·Peter GrabitzThomas Heimburg
Feb 28, 2002·Biophysical Journal·Heiko Heerklotz, Joachim Seelig
Apr 24, 2002·Physical Review. E, Statistical Physics, Plasmas, Fluids, and Related Interdisciplinary Topics·R WinterP Pfeifer
Jan 25, 2003·Annual Review of Biophysics and Biomolecular Structure·Tigran V Chalikian
Sep 25, 2003·Biochemistry·Wojciech DzwolakRoland Winter
May 14, 2004·Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry·Revanur Ravindra, Roland Winter
Feb 22, 2005·Proceedings of the National Academy of Sciences of the United States of America·Kirsten BaciaTeymuras Kurzchalia
Feb 25, 2005·Lipids·Ole G Mouritsen, Martin J Zuckermann
Aug 2, 2005·Biophysical Journal·Kara J TierneyMarjorie L Longo
Dec 6, 2005·Biophysical Journal·J HenriksenJ H Ipsen
Jan 5, 2006·Journal of the American Chemical Society·Chiara NicoliniRoland Winter
Sep 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·P A Rice, H M McConnell
Apr 6, 2006·Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry·Vytautas SmirnovasWojciech Dzwolak
Jun 2, 2006·Chemistry and Physics of Lipids·Alexander I GreenwoodJohn F Nagle
Oct 31, 2006·Biophysical Journal·Sagar A PanditH L Scott

❮ Previous
Next ❯

Citations

Apr 21, 2010·The European Physical Journal. E, Soft Matter·B BrüningT Salditt
Jul 14, 2009·General Physiology and Biophysics·Thalia T MillsJohn F Nagle
May 5, 2012·Progress in Lipid Research·Jean-Luc CacasSébastien Mongrand
Jan 25, 2011·Biophysical Chemistry·Yong ZhaiRoland Winter
Oct 28, 2008·Biochimica Et Biophysica Acta·Félix M GoñiJenifer L Thewalt
Mar 16, 2016·International Journal of Pharmaceutics·Giulia BonacucinaGiovanni F Palmieri
Oct 22, 2008·Biochimica Et Biophysica Acta·Aurelia R Honerkamp-SmithSarah L Keller
Aug 18, 2010·Biochimica Et Biophysica Acta·Luis G M BassoAntonio J Costa-Filho
Nov 18, 2010·Biophysical Journal·Parkson Lee-Gau ChongRoland Winter
Aug 1, 2012·Microscopy and Microanalysis : the Official Journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada·Andrew R Lupini, Stephen J Pennycook
Mar 9, 2017·Lab on a Chip·Ata DolatmoradiBilal El-Zahab
Nov 22, 2018·Soft Matter·Shamit ShrivastavaMatthias F Schneider
Aug 23, 2019·The Journal of Membrane Biology·Pranav Adhyapak, Shobhna Kapoor
Jun 24, 2014·Angewandte Chemie·Shobhna KapoorRoland Winter
Oct 28, 2015·Journal of Biomedical Optics·Ishay WohlMordechai Deutsch
Apr 27, 2017·Scientific Reports·Matti JavanainenIlpo Vattulainen
Sep 7, 2018·BioMed Research International·Aswin T SrivatsavShobhna Kapoor
Oct 13, 2017·Journal of Oleo Science·Wei-Han ChangYu-Min Yang
Feb 1, 2021·Progress in Biophysics and Molecular Biology·Shamit Shrivastava
Dec 18, 2019·Biochimica Et Biophysica Acta. Biomembranes·Renato M S CardosoMaria João Moreno
Feb 3, 2012·Journal of the American Chemical Society·Patrícia T MartinsMaria João Moreno
Jan 14, 2011·Langmuir : the ACS Journal of Surfaces and Colloids·Helen Y FanHeiko Heerklotz
Dec 28, 2018·Langmuir : the ACS Journal of Surfaces and Colloids·Paulo F Almeida
Aug 9, 2018·Langmuir : the ACS Journal of Surfaces and Colloids·Paulo F AlmeidaEmmanuel Tejada
May 7, 2020·Nano Letters·Yulia EygerisGaurav Sahay

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.