Effect of cholesterol feeding on lipolytic activities in high- and low-responding rhesus monkeys

Arteriosclerosis : an Official Journal of the American Heart Association, Inc
A K BhattacharyyaJ P Strong

Abstract

We compared the activities of lipoprotein (LPL) and hepatic lipase (HL) in postheparin plasma in groups of high- and low-responding rhesus monkeys fed a low cholesterol diet followed by a high cholesterol diet. Cholesterol feeding resulted in a two-phase response in lipolytic activities: an initial phase lasting about 21 days that was similar in the two groups, followed by the second phase in which major differences became apparent between the groups. In the initial phase, LPL and HL activities increased along with plasma cholesterol and high density lipoprotein (HDL) cholesterol, but there was no change in plasma triglycerides or apolipoprotein (apo) A-I levels. These changes suggest that both high and low responders respond in a similar manner to metabolize an increased lipid load and that both groups continue to remove triglyceride efficiently while cholesterol accumulation begins. The second phase (between 21 and 42 days and thereafter) in high responders was characterized by a decrease in LPL and HL activities along with plasma HDL cholesterol and apo A-I levels, continued increase in plasma cholesterol, and a slow increase in plasma triglycerides. In low responders, LPL activity was maintained at a high level, HL activity...Continue Reading

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Citations

Mar 28, 2018·Journal of Molecular Endocrinology·Jiung-Pang HuangLi-Man Hung
Mar 1, 1990·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·J Masuda, R Ross
May 1, 1991·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·J E FinchamJ A Strauss
May 1, 1990·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·L L Rudel, R J Star
Apr 1, 1992·Nutrition Reviews·K R Norum
Jul 1, 1997·The Journal of Nutrition·C P CarterD Y Hui

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