PMID: 1036094May 1, 1976

Effect of cholinergic drugs on serotonin metabolism and emotional reactions in rats

Farmakologiia i toksikologiia
A m Zharkovskiĭ, L Kh Allikmets

Abstract

The effects of physostigmine and m-cholinolytics on emotional reactivity, aggressiveness, exploratory behavior, along with simultaneous influence on the endogenous serotonin metabolism, enhanced by 1-tryptophan serotonin metabolism in the brain, were studied. Upon blocking the peripheral effects with methylatropine-physostigmine exerted a tranquillizing action on emotional reactions without producing any significant changes in the serotonin metabolism. Physostigmine acted as an antagonist to the traquillizing effect of 1-tryptophan, facilitating the catabolism of serotonin. M-cholinolytics--atropine and benactyzine exercised a tranquillizing action on emotional reactions, increasing the serotonin level in the forebrain and diencephalon.

Related Concepts

Aggressive Behavior
Atropine Derivatives
Behavior, Animal
Lucidil
Brain
Drug Antagonism
Regret
Hydroxyindoleacetic Acid
Eserine
Hydroxytryptamine

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