PMID: 1036094May 1, 1976

Effect of cholinergic drugs on serotonin metabolism and emotional reactions in rats

Farmakologiia i toksikologiia
A m Zharkovskiĭ, L Kh Allikmets


The effects of physostigmine and m-cholinolytics on emotional reactivity, aggressiveness, exploratory behavior, along with simultaneous influence on the endogenous serotonin metabolism, enhanced by 1-tryptophan serotonin metabolism in the brain, were studied. Upon blocking the peripheral effects with methylatropine-physostigmine exerted a tranquillizing action on emotional reactions without producing any significant changes in the serotonin metabolism. Physostigmine acted as an antagonist to the traquillizing effect of 1-tryptophan, facilitating the catabolism of serotonin. M-cholinolytics--atropine and benactyzine exercised a tranquillizing action on emotional reactions, increasing the serotonin level in the forebrain and diencephalon.

Related Concepts

Aggressive Behavior
Atropine Derivatives
Behavior, Animal
Drug Antagonism
Hydroxyindoleacetic Acid

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