Effect of cholinergic enhancement by pyridostigmine on growth hormone secretion in obese adults and children

Metabolism: Clinical and Experimental
E GhigoF Camanni

Abstract

In obesity the reduced growth hormone (GH) responses to several provocative stimuli including growth hormone-releasing hormone (GHRH) indicate a diminished somatotroph responsiveness but do not distinguish between primary pituitary and hypothalamic pathogenesis. However, it has been shown that the cholinergic system positively influences Gh secretion likely by modulating somatostatin release in a negative way. Thus, the effect of cholinergic activity enhancement by pyridostigmine (PD), an acetylcholinesterase inhibitor, on both basal and GHRH-induced GH secretion was studied in 14 obese subjects (eight adults and six children). Eighteen nonobese subjects (seven adults and 11 children) were studied as controls. In obese subjects the GHRH-induced GH increase was lower than in controls (peak, mean +/- SEM, adults, 9.2 +/- 2.7 v 16.8 +/- 5.7 ng/mL; children, 8.0 +/- 0.8 v 20.3 +/- 4.6 ng/mL) attaining statistical significance only in children group (P less than .02). The PD-induced GH response in the two obese groups was similar to that observed in relative controls (adults, 5.3 +/- 1.0 v 7.4 +/- 1.7 ng/mL; children, 9.6 +/- 1.6 v 13.3 +/- 1.4 ng/mL). PD clearly potentiated the GH response to GHRH in obese subjects, both adults (P ...Continue Reading

Citations

Nov 1, 1996·Journal of Pediatric Endocrinology & Metabolism : JPEM·L BeccariaG Chiumello
Mar 24, 2004·Paediatric Drugs·Mark HarrisWayne S Cutfield
Jun 1, 1992·Journal of Endocrinological Investigation·S LocheC Pintor
Apr 30, 1999·Physiological Reviews·E E MüllerD Cocchi
Feb 7, 2001·The Journal of Clinical Endocrinology and Metabolism·P RietschelS Grinspoon
Aug 4, 2005·The Journal of Clinical Endocrinology and Metabolism·Dorte GlintborgMarianne Andersen
Aug 26, 2021·Critical Reviews in Clinical Laboratory Sciences·Ozair AbawiErica L T van den Akker

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