Effect of cholinergic muscarinic receptor blockade on human growth hormone (GH)-releasing hormone-(1-44)-induced GH secretion in anorexia nervosa

The Journal of Clinical Endocrinology and Metabolism
H TamaiL F Kumagai

Abstract

The presence of hypothalamic disturbances affecting GH secretion in anorexia nervosa has been suggested, although a normal GH response to GH-releasing hormone (GHRH) administration has been shown in these patients. The present study was performed to investigate the role of acetylcholine in regulating GH secretion by using pirenzepine, which selectively blocks muscarinic cholinergic receptors. Paired tests were performed in nine anorexia nervosa patients (age +/- SEM, 19.1 +/- 1.2 yr; percent ideal body weight, -32.7 +/- 2.2%) and in six normal controls (20.1 +/- 0.3 yr; -3.1 +/- 1.8%). GHRH-(1-44) (1 microgram/kg) was infused iv with and without pirenzepine pretreatment (0.6 mg/kg, iv). Basal levels of GH were not different in anorexia nervosa compared to normal controls, whereas, somatomedin-C levels were significantly lower in anorexia nervosa patients. However, after pirenzepine administration, the GHRH-stimulated GH responses were completely blocked in normal controls, but not in anorexia nervosa patients. These results suggested that altered muscarinic cholinergic mechanism are involved in the modulation of GH secretion in patients with anorexia nervosa.

Citations

Aug 15, 1994·Biological Psychiatry·S S SkareC J Billington
Nov 5, 2003·Frontiers in Neuroendocrinology·Massimo ScacchiFrancesco Cavagnini
Apr 26, 2008·Endocrine Reviews·Andrea GiustinaErnesto Canalis
Dec 24, 2013·The Journal of Endocrinology·Pouneh K Fazeli, Anne Klibanski
May 19, 1998·Journal of Endocrinological Investigation·L GianottiE Ghigo
Jan 10, 2003·The Journal of Clinical Endocrinology and Metabolism·Virginie TolleBruno Estour
Nov 5, 1997·The Journal of Clinical Endocrinology and Metabolism·M ScacchiF Cavagnini
Sep 1, 1996·Psychological Medicine·J H Thakore, T G Dinan
Apr 30, 1999·Physiological Reviews·E E MüllerD Cocchi
Jul 25, 2007·Eating and Weight Disorders : EWD·L GianottiE Arvat

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anorexia Nervosa

Anorexia nervosa (AN) is a psychiatric condition characterized by severe weight loss and secondary problems associated with malnutrition. Here is the latest research on AN.