PMID: 2484612Jul 1, 1989Paper

Effect of chromium(III) on nucleolar RNA synthesis

Biological Trace Element Research
S OkadaM Tezuka

Abstract

The enhancement of hepatic nucleolar RNA synthesis induced by Cr(III) in partially hepatectomized rats and its mechanisms are described. Cr(III)-administered (0.5 mg Cr/kg, ip) and then partially hepatectomized rats were significantly enhanced in the hepatic nucleolar RNA synthesis at the very early stage of liver regeneration. This enhancement was caused both by the induction of newly found nucleolar Cr-bound protein of 70 kD (Cr-p70) and by the activation of nucleolar chromatin, both of which arose from nuclear accumulation of Cr together with partial hepatectomy. Studies on the mechanism of this enhancement indicated that the Cr-p70 bound to the activated nucleolar chromatin and loosened its higher-order structure, resulting in an increase of the B-form fraction of chromatin DNA. The degree of this loosening well correlated with the amount of Cr-p70 bound to chromatin and also with the extent of elevation of RNA synthesis. Some molecular species of nonhistone proteins in chromatin were found to play an important role in the interaction to Cr-p70. These results suggest a possibility that the action of Cr is involved in cell proliferation process.

References

Jun 1, 1984·Journal of Inorganic Biochemistry·S OkadaH Ohba
Nov 1, 1980·Mutation Research·A Léonard, R R Lauwerys
May 1, 1961·Proceedings of the Society for Experimental Biology and Medicine·C EDWARDSJ GLENN

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Citations

Jan 1, 1992·Biological Trace Element Research·W Mertz
Jul 10, 1998·Nutrition Reviews·W Mertz
Aug 17, 1999·Annual Review of Nutrition·H C Lukaski

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