PMID: 7018797Apr 1, 1981Paper

Effect of chronic and acute changes in sodium balance on the urinary excretion of prostaglandins E2 and F2 alpha in normal man

Clinical Science
M RathausJ Bernheim

Abstract

1. The effects of changes in sodium balance on renal prostaglandins have been hitherto studied mainly in experimental animals and the results have been controversial. In this study the 24 h urinary excretion of prostaglandins E2 and F2 alpha was measured by radioimmunoassay in seven normal subjects under basal conditions and after 5 days of a diet containing less than 20 mmol of sodium/day. Subsequently a sodium chloride (150 mmol/l: saline) load (300 mmol of sodium over 4 h) was infused and prostaglandins were again measured in hourly urine collections. Plasma renin activity and aldosterone were also measured under basal conditions, after the low sodium diet and at 2 and 4 h of the saline infusion. 2. Dietary sodium restriction was associated with a marked increase in prostaglandin E2 excretion (from 769.7 +/- 201.6 SEM to 1761.3 +/- 304.9 ng/24 h, P less than 0.0005). Prostaglandin F2 alpha also increased from 1187.0 +/- 390.1 to 1435.6 +/- 344.6 ng/24 h, but this was not statistically significant. The prostaglandin E2/prostaglandin F2 alpha ratio increased from 0.83 +/- 0.2 to 1.52 +/- 0.34 (P less than 0.01). Plasma renin activity and aldosterone rose significantly (P less than 0.05 and less than 0.0025 respectively). 3. Du...Continue Reading

Citations

Apr 1, 1990·Journal of Clinical Chemistry and Clinical Biochemistry. Zeitschrift Für Klinische Chemie Und Klinische Biochemie·M RathausM M Werber
Apr 1, 1986·European Journal of Clinical Investigation·J BernheimM Rathaus
Jul 1, 1984·Acta Physiologica Scandinavica·O M SejerstedF Kiil
Mar 9, 1999·Clinical Physiology·G C AgnoliL Stipo
Oct 1, 1989·Journal of the American College of Nutrition·J T JuddJ Dupont
Jan 1, 1982·Clinical and Experimental Hypertension. Part A, Theory and Practice·T MoriseR Takeda
May 17, 1982·Klinische Wochenschrift·P C WeberR Lorenz
Mar 1, 1988·The Journal of Urology·H HirayamaT Yamamoto
Sep 14, 2007·Scandinavian Journal of Urology and Nephrology·Christos KalaitzisStavros Touloupidis
Feb 1, 1983·European Journal of Clinical Investigation·M RathausJ Bernheim
Jan 1, 1984·The Journal of Pharmacy and Pharmacology·P J ChiuA Barnett
Apr 1, 1990·Prostaglandins, Leukotrienes, and Essential Fatty Acids·N KnoersL Monnens

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