Effect of chronic beta-blockade on QT interval in patients with liver cirrhosis

Journal of Hepatology
Andrea ZambruniM Bernardi

Abstract

QT interval prolongation is frequent in cirrhosis, predicts a poor prognosis and may trigger severe ventricular arrhythmias. Our aim was to evaluate the effect of chronic beta-blockade on QT prolongation. Clinical and laboratory evaluation, ECG and hepatic vein pressure gradient (HVPG) measurement were performed in 30 cirrhotic patients before and 1-3 months after prophylactic nadolol. QT was corrected for heart rate by the cirrhosis-specific formula and other formulas. QT(cirrhosis) was prolonged in 10 patients (33%); HVPG was increased in all cases. QT(cirrhosis) was correlated with the Child-Pugh score (r=0.40; p=0.027). Nadolol shortened QT interval only with the Bazett formula (p=0.01), remaining unchanged with the other formulas. The QT interval shortened only if prolonged at baseline (from 473.3+/-5.5 to 458.4+/-6.5 ms; p=0.007), while it lengthened when normal (from 429.8+/-3.1 to 439.3+/-2.9 ms; p=0.01). QTc changes were directly related to the baseline value (p<0.001). HVPG decreased from 19.4+/-0.8 to 15.6+/-1.3 mmHg (p=0.004). The HVPG changes did not correlate with QTc changes. Chronic beta-blockade shortens the QT interval only in patients with prolonged baseline values, and this is likely due to a direct cardiac ...Continue Reading

References

Sep 1, 1992·Journal of Clinical Gastroenterology·L B SteinS C Brozena
Sep 15, 1992·The American Journal of Cardiology·A SagieD Levy
Aug 1, 1973·The British Journal of Surgery·R N PughR Williams
Jun 1, 1981·British Heart Journal·N Edvardsson, S B Olsson
May 1, 1996·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·R MohamedJ M Neuberger
Jan 13, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M BernardiG Raimondo
Aug 29, 1998·Journal of Hepatology·J H HenriksenN J Christensen
Oct 26, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·C MerkelA Gatta
Nov 26, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Christophe BureauJean-Pierre Vinel
Aug 5, 2003·Liver International : Official Journal of the International Association for the Study of the Liver·Jasdeep Singh Bal, Paul J Thuluvath
Sep 17, 2003·The Journal of Clinical Investigation·Robert S Kass, Arthur J Moss
Mar 5, 2004·The New England Journal of Medicine·Dan M Roden
Jun 18, 2004·The New England Journal of Medicine·Panagiotis Korantzopoulos, Konstantinos Siogas
Aug 10, 2004·Gastroenterology·Carlo MerkelUNKNOWN Gruppo Triveneto per l'Ipertensione Portale
Nov 10, 2004·Journal of Electrocardiology·Shen LuoPeter W Macfarlane
Aug 9, 2005·Journal of Hepatology·Henriette YttingSøren Møller
Sep 17, 2005·Progress in Biophysics and Molecular Biology·C A WardW R Giles
Mar 3, 2006·Journal of Hepatology·Andrea ZambruniMauro Bernardi
Jan 19, 2007·Journal of Cardiovascular Electrophysiology·Andrea ZambruniMauro Bernardi
Feb 28, 2007·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Patrick S KamathUNKNOWN Advanced Liver Disease Study Group
Mar 27, 2007·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·A MilaniP Pola
Mar 29, 2007·Orphanet Journal of Rare Diseases·Soon Koo BaikSamuel S Lee

❮ Previous
Next ❯

Citations

Aug 12, 2009·Hepatology International·Florence Wong
Jul 16, 2013·European Heart Journal·Søren Møller, Mauro Bernardi
Jun 6, 2012·Critical Care Research and Practice·Antonio FigueiredoPaulo Marcelino
Nov 13, 2013·Nature Reviews. Gastroenterology & Hepatology·Signe WieseSøren Møller
Dec 18, 2013·Scandinavian Journal of Gastroenterology·Emilie Kristine DahlAleksander Krag
Jan 16, 2009·Scandinavian Cardiovascular Journal : SCJ·Jens H Henriksen, Søren Møller
Mar 20, 2015·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Jan KlimasSimon W Rabkin
Nov 19, 2014·Digestive Diseases and Sciences·Dimitrios S KaragiannakisJiannis Vlachogiannakos
Oct 9, 2012·International Journal of Cardiology·Søren MøllerFlemming Bendtsen
May 19, 2017·World Journal of Cardiology·Sun Moon KimAlison L Bailey
Apr 5, 2013·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Waqas QureshiFatima Khalid
Apr 7, 2018·Minerva anestesiologica·Giuliana ScarpatiOrnella Piazza
Feb 4, 2010·Current Opinion in Anaesthesiology·Federico Polli, Luciano Gattinoni
Feb 26, 2019·Expert Review of Gastroenterology & Hepatology·Søren MøllerFlemming Bendtsen
Feb 13, 2009·Expert Review of Gastroenterology & Hepatology·Søren MøllerAleksander Krag
Mar 17, 2012·Pediatric Transplantation·Nitin MadanRica Arnon
Apr 8, 2015·World Journal of Hepatology·Suehana Rahman, Susan V Mallett
Jul 10, 2010·American Journal of Physiology. Gastrointestinal and Liver Physiology·Søren MøllerFlemming Bendtsen
Sep 25, 2014·Journal of Pediatric Gastroenterology and Nutrition·Coskun CeltikSemra Sökücü
Jan 25, 2020·Journal of Hepato-biliary-pancreatic Sciences·Ajay Kumar Jha, Suman Lata
Feb 18, 2011·Current Opinion in Critical Care·Hongqun Liu, Samuel S Lee
Dec 14, 2011·Expert Review of Gastroenterology & Hepatology·Mauro BernardiGiacomo Zaccherini
Apr 16, 2015·European Journal of Gastroenterology & Hepatology·Axel JosefssonEvangelos Kalaitzakis
Jul 14, 2020·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Nikhilesh R Mazumder, Lisa B VanWagner
Oct 30, 2019·The Egyptian Heart Journal : (EHJ) : Official Bulletin of the Egyptian Society of Cardiology·Ahmed E GaafarMohamed El Kassas
Feb 21, 2019·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·M V H CarvalhoV N Carvalho
Oct 28, 2017·American Journal of Physiology. Gastrointestinal and Liver Physiology·Troels M BuskSøren Møller
May 25, 2012·Liver International : Official Journal of the International Association for the Study of the Liver·Axel JosefssonEvangelos Kalaitzakis
Jul 11, 2012·Liver International : Official Journal of the International Association for the Study of the Liver·Franco TrevisaniMauro Bernardi
Apr 26, 2014·Annals of Noninvasive Electrocardiology : the Official Journal of the International Society for Holter and Noninvasive Electrocardiology, Inc·Divyang PatelJan Němec
Feb 4, 2016·World Journal of Hepatology·Mara BarbosaJosé Cotter
Jan 15, 2020·Gastroenterology Research and Practice·Mattia BellanMario Pirisi
Jan 20, 2019·Digestive Diseases and Sciences·Eleni TheocharidouChristos S Mantzoros
Nov 12, 2015·World Journal of Gastroenterology : WJG·Luis Ruiz-del-Árbol, Regina Serradilla
Jul 12, 2020·Current Gastroenterology Reports·Ki Tae YoonSamuel S Lee
Dec 16, 2020·Clinical and Molecular Hepatology·Ki Tae YoonSamuel S Lee
Aug 21, 2021·Deutsche medizinische Wochenschrift·Philipp KasperGuido Michels
Dec 15, 2010·Journal of Hepatology·Cristina RipollRafael Bañares

❮ Previous
Next ❯

Related Concepts

Related Feeds

Atrial Fibrillation

Atrial fibrillation is a common arrhythmia that is associated with substantial morbidity and mortality, particularly due to stroke and thromboembolism. Here is the latest research.

Antiarrhythmic Agents: Mechanisms of Action

Understanding the mechanism of action of antiarrhythmic agents is essential in developing new medications as treatment of cardiac arrhythmias is currently limited by the reduced availability of safe and effective drugs. Discover the latest research on Antiarrhythmic Agents: Mechanism of Action here.

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.