Effect of chronic blockade of angiotensin II-receptor subtypes on aortic compliance in rats with myocardial infarction

Journal of Cardiovascular Pharmacology
D L CeilerJ F Smits

Abstract

This study was undertaken to investigate changes in aortic geometry and compliance after long-term blockade of angiotensin receptors type 1 (AT1) and AT2 receptors under basal conditions and after myocardial infarction (MI). Sham-operated (sham) or MI rats received either no treatment, AT1 antagonist GR138950C (GR; 2 mg/kg/day i.v.), or AT2 antagonist PD123319 (PD; 3 mg/kg/day s.c.). After 3 weeks, mean arterial blood pressure (MAP) was measured. Thoracic aorta diastolic diameter (D[dia]), compliance coefficient (CC), and distensibility coefficient (DC) were determined noninvasively in anesthetized rats by using ultrasound and wall tracking. After the rats were killed, histologic measurements were made on aortic cross sections. In sham rats, MAP was reduced by GR treatment (76 +/- 6 vs. 106 +/- 5 mm Hg), but not by PD. D(dia) was reduced in both GR-treated (1.74 +/- 0.08 vs. 2.09 +/- 0.05 mm) and PD-treated (1.83 +/- 0.05 vs. 2.09 +/- 0.05 mm) sham rats. CC and DC were not modified by either treatment. Although media cross-sectional area was not affected by either GR or PD treatment in sham rats, media thickness and media/lumen ratio were increased in both cases. Induction of MI had no effect on aortic structure, geometry, or m...Continue Reading

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Citations

Sep 12, 2000·Current Hypertension Reports·J B Park, E L Schiffrin
Oct 8, 2003·British Journal of Pharmacology·Robert E WiddopTracey A Gaspari
Mar 1, 2003·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Tina ChabrashviliChristopher S Wilcox
Feb 9, 2002·American Journal of Physiology. Heart and Circulatory Physiology·David Schachter, James C Sang
Nov 25, 1998·Biochemical and Biophysical Research Communications·P ZahradkaL Saward

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