Effect of chronic diuretic treatment on the plasma renin-angiotensin-aldosterone system in essential hypertension

British Journal of Clinical Pharmacology
P LijnenA Amery

Abstract

1 Chronic treatment with a constant dose of hydrochlorothiazide or tienilic acid increases plasma renin activity (PRA) acutely to reach a maximum within the first week. 2 During chronic diuretic therapy from 1 month to 1 year, PRA remained elevated at a rather constant level, though this was somewhat lower than the maximum level reached after 1 week. 3 A significant (P less than 0.01) correlation (r = 0.74) between changes in plasma angiotensin II and renin activity provoked by chronic treatment for 3 months with hydrochlorothiazide and tienilic acid was found. 4 The increase in plasma aldosterone during chronic treatment with hydrochlorothiazide and tienilic acid (1000 mg) is related (r = 0.68; P less than 0.01) to the rise in plasma angiotensin II.

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Citations

Aug 1, 1991·Cardiovascular Drugs and Therapy·P LijnenA Amery
Jan 16, 2010·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Toshihiro KitaKazuo Kitamura
Aug 24, 2010·Vascular Health and Risk Management·Francesca CagnoniMaurizio Destro
Jul 10, 2008·Clinical Pharmacokinetics·Sujata VaidyanathanWilliam P Dole
Jan 1, 1987·Cardiovascular Drugs and Therapy·I L Natoff
Jun 5, 2015·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Miki HosakaYutaka Imai
May 3, 2013·Cardiology·Massimo Volpe, Thomas Unger
Oct 30, 2008·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Rainer DietzDeborah L Keefe
Feb 6, 2019·International Journal of Molecular Sciences·Tuba M AnsaryAkira Nishiyama
Feb 27, 2019·Journal of Veterinary Internal Medicine·Marisa K AmesBertram Pitt
Mar 17, 2020·Pediatric Pulmonology·Jeffrey L Segar
May 11, 2012·Journal of Hypertension·Hirohito MetokiUNKNOWN J-HOME-AI Study group
Apr 11, 2020·Journal of Clinical and Translational Hepatology·Anand V KulkarniD Nageshwar Reddy
Jul 1, 2020·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Rasmus DreierJørgen L Jeppesen
Sep 24, 2019·Frontiers in Pharmacology·Robert M Rapoport, Manoocher Soleimani
Jul 21, 2017·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Yoshiyuki OkadaQi Fu
Sep 29, 2020·American Journal of Physiology. Renal Physiology·Justin D SprickJeanie Park

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