Effect of chronic erythropoietin administration on plasma iron in newborn lambs

Biology of the Neonate
C PetersJ A Widness

Abstract

Erythropoietin, the primary stimulator of erythropoiesis, represents an important potential therapy for the anemia of prematurity. Enhancement of the therapeutic benefit of recombinant human erythropoietin (rhEp) in very-low-birth-weight infants will require a better understanding of rhEp's pharmacodynamic effects including its interaction with iron in stimulating erythropoiesis. The purpose of this study was to determine the effects of chronic rhEp administration on plasma iron levels and hematopoiesis using a twin lamb model. Nine pairs of twin lambs in which one twin was randomized to receive rhEp, and the other saline, were studied during a 1-week baseline and a subsequent 4- to 5-week treatment period. The effects of therapy on plasma iron levels and erythropoiesis were measured by integrating the areas under the concentration-time curves (AUC) of the study variables. During the rhEp treatment period, significantly greater negative daily AUCs were observed in the rhEp-treated lambs for plasma iron concentration (p = 0.0008), while significantly greater positive daily AUCs were observed for hemoglobin concentration (p = 0.04) and reticulocyte count (p = 0.02). In the rhEp-treated group, pretreatment iron concentrations were...Continue Reading

Citations

May 23, 2007·Journal of Pharmacokinetics and Pharmacodynamics·Kevin J FreisePeter Veng-Pedersen
Apr 18, 2009·Pediatrics International : Official Journal of the Japan Pediatric Society·Srividya NeelakantanPeter Veng-Pedersen
May 4, 2002·Seminars in Neonatology : SN·R Rao, M K Georgieff
Aug 8, 2006·Biopharmaceutics & Drug Disposition·S NeelakantanP Veng-Pedersen
Apr 13, 2007·Clinical Pharmacology and Therapeutics·J A WidnessP Veng-Pedersen
Aug 18, 2020·JAMA Pediatrics·Sandra E JuulUNKNOWN Preterm Erythropoietin Neuroprotection Trial Consortium
Nov 6, 2004·Biopharmaceutics & Drug Disposition·N H Al-HunitiP Veng-Pedersen
Jan 22, 1998·The American Journal of Physiology·S F GuiangJ A Widness
Aug 10, 1999·Biopharmaceutics & Drug Disposition·P Veng-PedersenL S Lowe
Apr 6, 2000·Journal of Applied Physiology·J A WidnessH Bard

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