PMID: 11329498May 1, 2001Paper

Effect of chronic ethanol consumption on protective T-helper 1 and T-helper 2 immune responses against the parasites Leishmania major and Strongyloides stercoralis in mice

Alcoholism, Clinical and Experimental Research
A J KrolewieckiD Abraham

Abstract

Chronic alcohol consumption has been associated with significant increases in the prevalence of infectious diseases, and it has been suggested that these increases are caused by a direct effect of ethanol on the immune response. The objective of this study was to determine whether chronic ethanol consumption would affect the development of protective immunity to Leishmania major, which is controlled by the T-helper 1 (Th1) subset of CD4 cells, and Strongyloides stercoralis, which is controlled by the Th2 subset. Mice were fed ethanol-containing liquid diet (25% ethanol-derived calories), liquid isocaloric diet without ethanol, or solid chow and then exposed to either of the two parasites. The ability of the mice chronically consuming alcohol to eliminate the infections was determined, as were the levels of parasite-specific humoral and cellular immune responses. Mice chronically consuming alcohol were capable of eliminating both of these infections in a manner identical to the control mice. In addition, splenocytes from mice chronically consuming alcohol infected with L. major produced nitric oxide at the same levels as in control mice. Antibody responses were altered in a manner suggesting an increase in Th2 immunity and a dec...Continue Reading

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Citations

Apr 15, 2004·Journal of Neuroimmunology·Hsing-Cheng LiuSy-Jye Leu
Feb 14, 2004·Medical Hypotheses·George E Davis, Walter E Lowell
Feb 5, 2004·Brain, Behavior, and Immunity·Piotr TrzonkowskiAndrzej Myśliwski
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Mar 4, 2003·Revista Da Sociedade Brasileira De Medicina Tropical·Maria P Zago-GomesFausto E L Pereira

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