Effect of chronic ethanol feeding on testicular content of enzymes required for testosteronogenesis

Alcoholism, Clinical and Experimental Research
Y B ChiaoD H van Thiel

Abstract

Ethanol is a known inducer of microsomal enzymes as well as a testicular toxin. In order to evaluate the effect of chronic ethanol ingestion upon the microsomal enzymes required for testosterone synthesis, we examined the activity of four testicular enzymes (3 beta-hydroxysteroid dehydrogenase/isomerase, 17 alpha-hydroxylase, 17,20-lyase, and 17 beta-hydroxysteroid dehydrogenase) in 14 pairs of adult chronic alcohol-fed rats and their age-matched isocaloric controls. Ethanol feeding enhanced the activity of 17,20-lyase when expressed as either activity/mg of protein (p less than 0.05) or activity/g of testis (P less than 0.025). Similarly, the activity of 17 alpha-hydroxylase was increased in testes of the alcohol-fed animals (p less than 0.025) compared to controls. In contrast, chronic ethanol feeding reduced total activity of 3 beta-hydroxysteroid dehydrogenase/isomerase in alcohol-fed animals (p less than 0.05) compared to controls. No effect of ethanol feeding was seen on activity of 17 beta-hydroxysteroid dehydrogenase. Based upon these studies we conclude that chronic ethanol ingestion (1) increases testicular 17 alpha-hydroxylase and 17,20-lyase and (2) reduces 3 beta-hydroxysteroid dehydrogenase/isomerase in rat testic...Continue Reading

References

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Citations

Jan 1, 1983·Pharmacology, Biochemistry, and Behavior·R A AndersonL J Zaneveld
Jan 1, 1989·Pharmacology & Therapeutics·D H Van ThielR E Tarter
Sep 25, 1999·Clinics in Dermatology·R Wolf
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Dec 3, 1998·Alcoholism, Clinical and Experimental Research·Q ShiM A Emanuele
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Aug 26, 2006·Alcoholism, Clinical and Experimental Research·Melissa HermanCatherine Rivier
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Jan 1, 1983·Alcoholism, Clinical and Experimental Research·A Galvão-TelesE Monteiro
Jan 1, 1983·Alcoholism, Clinical and Experimental Research·V K BhallaM E Newman
Jan 1, 1983·Alcoholism, Clinical and Experimental Research·Y B Chiao, D H Van Thiel
Nov 7, 2001·Alcoholism, Clinical and Experimental Research·V K SrivastavaW Les Dees
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Sep 25, 1999·Clinics in Dermatology·A Shulman, R Wolf

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