Effect of chronic exposure to acetaminophen and lincomycin on Japanese medaka (Oryzias latipes) and freshwater cladocerans Daphnia magna and Moina macrocopa, and potential mechanisms of endocrine disruption

Chemosphere
Pan-Gyi KimKyungho Choi

Abstract

Chronic toxicity of acetaminophen and lincomycin were evaluated using freshwater organisms including two crustaceans (Daphnia magna and Moina macrocopa) and a fish (Oryzias latipes). H295R, a human adrenal cell was also used to understand the effects on steroidogenesis. In 21 d D. magna exposure, survival NOEC was found at 5.72 mg L(-1) and no reproduction related effects were noted at this level of exposure to acetaminophen, while 21 d survival or growth effects were not observed even at the highest exposure levels (153 mg L(-1)) for lincomycin. In the chronic fish toxicity test, significant reduction in juvenile survival was observed at 30 d post-hatch (dph) at 95 mg L(-1) of acetaminophen, and 0.42 mg L(-1) of lincomycin. After the exposure to both pharmaceuticals, vitellogenin levels tended to increase in male fish at 90 dph. In the eggs which were prenatally exposed to 9.5 mg L(-1) of acetaminophen, reduced hatchability was observed. The results of H295R cell assay showed that both pharmaceuticals could alter steroidogenic pathway and increase estrogenicity. Endocrine disruption potentials and their ecological implication may deserve further studies. Our observations suggest however that ecological risks of both pharmaceut...Continue Reading

References

Aug 1, 1994·Archives of Environmental Contamination and Toxicology·K Fent, W Meier
May 7, 1998·Chemosphere·B Halling-SørensenS E Jørgensen
Mar 18, 1999·Toxicology and Applied Pharmacology·E Harnagea-TheophilusM R Miller
May 20, 1999·Toxicological Sciences : an Official Journal of the Society of Toxicology·M R MillerS Ong
Feb 16, 2002·Methods : a Companion to Methods in Enzymology·K J Livak, T D Schmittgen
Aug 6, 2004·Chemosphere·S WiegelA Wanke
May 23, 2007·Proceedings of the National Academy of Sciences of the United States of America·Karen A KiddRobert W Flick
Mar 13, 2009·Toxicological Sciences : an Official Journal of the Society of Toxicology·Tisha C King HeidenRichard E Peterson
Sep 29, 2009·Journal of Critical Care·Rachel S GreenbergJeffrey D Hasday

❮ Previous
Next ❯

Citations

Apr 14, 2015·Drug and Chemical Toxicology·Laira L Damasceno de OliveiraBruno Nunes
Sep 14, 2015·Water Research·A ButkovskyiG Zeeman
May 7, 2015·Critical Reviews in Toxicology·Matthew D OverturfDouglas A Holdway
Apr 18, 2013·Regulatory Toxicology and Pharmacology : RTP·H TinwellR Bars
Apr 29, 2014·Regulatory Toxicology and Pharmacology : RTP·Camille Bouissou-SchurtzDominique Masset
Mar 9, 2017·Environmental Management·E C de VasconcelosC M R de Oliveira
Mar 20, 2021·Environmental Science and Pollution Research International·Ana Paula Sousa, Bruno Nunes
May 1, 2021·Environmental Science and Pollution Research International·Wulan KoagouwCorina Ciocan
Apr 2, 2018·Ecotoxicology and Environmental Safety·Sivashankar RenukaFrederick Clara-Bindu
Aug 18, 2020·Environmental Science & Technology·Tom TopazBenny Chefetz

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.