Effect of chronic fluoxetine treatment on male and female rat erythrocyte and prefrontal cortex fatty acid composition.

Progress in Neuro-psychopharmacology & Biological Psychiatry
Robert K McNamaraRonald Jandacek

Abstract

Omega-3 (n-3) polyunsaturated fatty acids (PUFA) and fluoxetine (FLX) have additive effects in the treatment of major depressive disorder, and FLX up-regulates genes that regulate fatty acid biosynthesis in vitro. Although these data suggest that FLX may augment n-3 fatty acid biosynthesis, the in vivo effects of FLX treatment on PUFA biosynthesis and peripheral and central membrane compositions are not known. In the present study, male and female rats were treated with FLX (10 mg/kg/day) through their drinking water for 30 days (P60-P90). Plasma FLX and norfluoxetine (NFLX) concentrations were determined by liquid chromatography tandem mass spectrometry, and erythrocyte and prefrontal cortex (PFC) fatty acid composition determined by gas chromatography. To confirm central effects of FLX, serotonin turnover in the PFC was determined by high performance liquid chromatography. Chronic FLX treatment resulted in clinically-relevant plasma FLX concentrations in male and female rats, and significantly decreased serotonin turnover in the PFC. After correcting for multiple comparisons, chronic FLX treatment did not significantly alter erythrocyte fatty acid composition in male or female rats. Chronic FLX treatment significantly and sel...Continue Reading

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Citations

Oct 9, 2012·Expert Review of Neurotherapeutics·Robert K McNamara, Francis E Lotrich
Feb 20, 2019·Frontiers in Cellular Neuroscience·Lei MaRena Li
Jul 22, 2018·Biochemical Pharmacology·Maria BoveLuigia Trabace
Aug 8, 2021·International Journal of Molecular Sciences·Anna TkachevPhilipp Khaitovich

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