PMID: 9547857Apr 21, 1998Paper

Effect of chronic growth hormone administration on skeletal muscle in dogs

Toxicologic Pathology
S Molon-NoblotM J van Zwieten

Abstract

Administration of growth hormone (GH) results in increased body weight gain in dogs. Increased body weight gain is believed to be a result of the trophic effect of GH on the musculoskeletal system. However, edema is one of the side effects described in man following exogenous GH administration. Thus, the objective of this study was to determine if the expected increased weight gain in GH-treated dogs is a result of increased muscle mass. Porcine growth hormone (pGH), administered subcutaneously to beagle dogs at doses of 0.025, 0.1, and 1 IU/kg/day for 14 wk, resulted in elevated serum GH and insulin-like growth factor-1 (IGF-1) levels (see accompanying paper, Prahalada et al). This was associated with a significant increase in body weight gain and weights of the cranial tibialis muscle in both male and female dogs. The increased muscle mass likely contributed to the significant increase in body weight gain seen in both sexes. Quantitative analysis of skeletal muscle sections stained for ATPase activity showed increases in type I (slow twitch) and type II (fast twitch) myofiber sizes in mid- and high-dose males and in high-dose females. The ratio of type I and type II muscle fibers remained unchanged. Hypertrophic myofibers wer...Continue Reading

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Citations

Nov 2, 2005·The Veterinary Clinics of North America. Small Animal Practice·Denis J Marcellin-LittleRobert Taylor
Jul 7, 2005·Scandinavian Journal of Medicine & Science in Sports·S Doessing, M Kjaer
Mar 21, 2012·Scandinavian Journal of Medicine & Science in Sports·K M HeinemeierM Kjaer
Aug 30, 2003·Molecular Therapy : the Journal of the American Society of Gene Therapy·Amir S KhanRuxandra Draghia-Akli
Dec 25, 2002·Molecular Therapy : the Journal of the American Society of Gene Therapy·Ruxandra Draghia-AkliRobert H Carpenter
Mar 11, 2003·Technology in Cancer Research & Treatment·Ruxandra Draghia-AkliPatricia A Brown
Aug 10, 2000·Toxicologic Pathology·S Molon-NoblotM J van Zwieten
Apr 21, 1998·Toxicologic Pathology·C A Bondy
Apr 10, 2004·Cancer Gene Therapy·Catherine M ToneRuxandra Draghia-Akli
Feb 23, 2018·Veterinary Medicine and Science·Linda RhodesErnst Heinen
Oct 24, 2017·Journal of Veterinary Pharmacology and Therapeutics·J A WoffordE Heinen

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