Effect of chronic infusion of placental lactogen on ovine fetal growth in late gestation

Domestic Animal Endocrinology
P A SchoknechtA W Bell

Abstract

To test the hypothesis that placental lactogen (PL) is a humoral regulator of fetal growth, six singleton sheep fetuses received a continuous intravenous fusion of 1.2 mg/d of purified ovine PL (oPL) for 14 d, beginning on Day 122 of gestation. The plasma concentration of oPL was approximately four-fold higher in infused fetuses than in six control fetuses that received a continuous infusion of saline. The circulating insulin-like growth factor 1 (IGF-I) concentration was also significantly elevated in PL-infused fetuses (43.1 +/- 1.7 vs. 31.9 +/- 4.1 ng/ml; P < 0.05). Animals were slaughtered on Day 136, and the placenta and all major fetal tissues were dissected, weighed, and subsampled for chemical analysis. Fetal weight and crown-rump length were not significantly affected by treatment; however, the aggregate weight of the brain, liver, lungs, and heart tended to be larger (85.3 +/- 2.1 vs. 79.9 +/- 1.5 g/kg fetus; mean +/- SE, P = 0.07) and the thyroid gland was smaller (0.18 +/- 0.1 vs. 0.26 +/- 0.02 g/kg fetus; P < 0.05) in the PL-infused fetuses. The livers of the PL-infused fetuses had also accumulated additional glycogen (13.1 +/- 1.7 vs. 8.4 +/- 0.7 g; P < 0.05). In late gestation, PL within the fetal compartment inc...Continue Reading

References

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Citations

Aug 7, 2002·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·M J Waters, P L Kaye
Mar 1, 2000·Clinical Obstetrics and Gynecology·N P Illsley
Feb 5, 2010·Acta Veterinaria Scandinavica·Andrea Vivian Alvarez-OxileyJean-François Beckers
May 17, 2007·Reproduction : the Official Journal of the Society for the Study of Fertility·Richard G LeaJacqueline M Wallace
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Jul 27, 2014·Reproductive Sciences·Thorsten BraunJohn R G Challis
May 16, 2002·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Richard A EhrhardtYves R Boisclair
Feb 19, 2016·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Callie M BakerRussell V Anthony
Oct 16, 1999·European Journal of Biochemistry·R LiangR V Anthony
Jul 24, 2004·Animal Reproduction Science·E Gootwine
Oct 29, 2008·Molecular and Cellular Endocrinology·Chae Kwan LeeJin Hong Ahn

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