PMID: 8612440Sep 1, 1995Paper

Effect of chronic intermittent intravenous insulin therapy on antihypertensive medication requirements in IDDM subjects with hypertension and nephropathy

Diabetes Care
T T AokiR Meisenheimer

Abstract

The prevalence of systemic hypertension is increased in patients with diabetes. In this prospective, randomized, crossover clinical trial, we assessed antihypertensive effects of chronic intermittent intravenous insulin therapy (CIIIT) on insulin-dependent diabetes mellitus (IDDM) subjects with hypertension and nephropathy by monitoring the amount of antihypertensive medication (AHM) required to maintain blood pressure (BP) < or = 140/90 mmHg. After a stabilization period, 26 hypertensive IDDM subjects were randomly assigned to a control or treatment phase for 3 months and then crossed over into the opposite phase for another 3 months. Addition of CIIIT during the treatment phase was the only procedural difference between the control and treatment phases. The AHM dosage requirements for maintenance of the baseline BP levels decreased significantly (46%; P < 0.0001) and linearly over time (P < 0.0058) during the treatment phase, while remaining essentially unchanged during the control phase. Our data suggest that CIIIT markedly improves BP control, as evidenced by the significantly reduced AHM dosage requirements in subjects with IDDM and hypertension, possibly through an improvement in vascular reactivity.

Citations

Jul 27, 2001·Diabetes Technology & Therapeutics·T T AokiJ H Ahn
Jun 23, 2011·International Journal of Nephrology and Renovascular Disease·John A D'EliaLarry A Weinrauch
Nov 25, 2000·Metabolism: Clinical and Experimental·G E DaileyJ A D'Elia
May 19, 2009·Medical Hypotheses·M Reza MirbolookiJonathan R T Lakey
Jul 15, 2004·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·T T AokiR Meisenheimer
Sep 25, 2018·The Cochrane Database of Systematic Reviews·Clement LoSophia Zoungas
Jul 9, 2010·The Cochrane Database of Systematic Reviews·Chamila Geeganage, Philip Mw Bath
Jun 11, 2020·The Cochrane Database of Systematic Reviews·Emily ReeveDanijela Gnjidic
Jun 14, 2019·Current Therapeutic Research, Clinical and Experimental·Shu DongJonathan R T Lakey

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