Effect of chronic intra-accumbens administration of the TRH analogue CG3509 on histamine-induced behaviour in the rat

British Journal of Pharmacology
L J Bristow, G W Bennett

Abstract

1. The present study has investigated the effect of chronic intra-accumbens administration of the thyrotrophin-releasing hormone (TRH) analogue, CG3509, on CG3509- and histamine-induced spontaneous motor activity and brain TRH-like immunoreactive (TRH-LI) levels in the rat. 2. Chronic intra-accumbens administration of CG3509 (5 x 5 micrograms over 3 days) induced: (a) a significant (P less than 0.05) reduction in intra-accumbens CG3509 (0.5 micrograms)-induced hyperactivity, (b) reduced levels of TRH-LI in the nucleus accumbens but not other brain regions, (c) a marked increase (107%, P less than 0.01) in histamine-induced non-locomotor hyperactivity. 3. The present results demonstrate that alteration of central TRH function following treatment with a TRH analogue enhances the effect of intra-accumbens histamine on behavioural hyperactivity, possibly via changes in H1 receptors and suggest that the neuropeptide, TRH and histamine interact in behavioural arousal mechanisms in rat brain.

References

May 1, 1979·Pharmacology, Biochemistry, and Behavior·C A Marsden, B King
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Mar 1, 1972·Endocrinology·R M Bassiri, R D Utiger
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Dec 1, 1983·Regulatory Peptides·N A Sharif, D R Burt

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Citations

Jul 16, 2008·Physiological Reviews·Helmut L HaasOliver Selbach

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