PMID: 6989177Jan 1, 1980Paper

Effect of chronic intrarenal prostaglandin E2 infusion and angiotensin II blockade on arterial pressure in the dog

Advances in Prostaglandin and Thromboxane Research
G M Hockel, A W Cowley

Abstract

The present investigation demonstrates that chronic intrarenal PGE2 infusion results in a PRA-induced increase in arterial pressure. This conclusion is supported by an 8-fold rise in PRA and the marked reduction of arterial pressure during saralasin and CEI infusion. If the chronic effects of endogenously released PGE2 are similar to arterial administration, then the net effect of chronically elevated renal PGE2 in the dog appears to be a moderate, sustained hypertension.

Related Concepts

Angiotensin II, Val(5)-
Diastolic Blood Pressure
Lopirin
Canis familiaris
Parenteral Infusion
Osmolality
Proline
Prostaglandins E
Preprorenin
Sodium

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