Effect of chronic ischemia on glucose metabolism of rabbit urinary bladder

The Journal of Urology
A T LinR M Levin

Abstract

The effect of chronic ischemia on glucose metabolism of the rabbit urinary bladder was studied. Unilateral ischemia was produced by ligation of one of the two vesical arteries which supply the rabbit bladder. Two weeks after the operation, the in vitro glucose metabolism of normal bladder tissue was compared to the glucose metabolism of tissue isolated from both the ischemic side and contralateral (non-ischemic) side of the ischemic bladder. The results can be summarized as follows: 1) ischemic and contralateral side bladder tissues contained less glycogen than normal; 2) glucose utilization was higher in the ischemic and contralateral side tissues; 3) ischemic and contralateral side tissues incorporated more glucose into lactate and produced more total lactate than normal tissues; 4) whereas contralateral side tissue produced more 14CO2 than ischemic side tissue, the ability of normal bladder tissue to form 14CO2 is significantly higher than both ischemic and contralateral side tissues; 5) the degree of reduced CO2 production correlated well with previous studies on the contractile response of smooth muscle strips isolated from the ischemic and contralateral sides, and the reduced functional ability of the in vitro whole bladd...Continue Reading

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Citations

Feb 13, 2007·Urologia Internationalis·Aydin YenilmezSetenay Oner
Mar 1, 2012·Lower Urinary Tract Symptoms·Alex Tong Long Lin, Yung-Shun Juan
Jan 1, 1996·Neurourology and Urodynamics·B SoyupakN Haugaard
Jan 1, 2008·Molecular and Cellular Biochemistry·Tomoharu KonoMotoaki Saito
Aug 21, 2007·The Journal of Urology·Jeroen R ScheepeDirk J Kok
May 24, 2013·The Aging Male : the Official Journal of the International Society for the Study of the Aging Male·Sherif Azab

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