Effect of chronic maternal ethanol administration on glutamate and N-methyl-D-aspartate binding sites in the hippocampus of the near-term fetal guinea pig

Alcohol
S Abdollah, J F Brien

Abstract

The objective of this study was to determine the effect of chronic maternal administration of ethanol on hippocampal L-glutamate (glutamate) and N-methyl-D-aspartate (NMDA) binding sites in the near-term fetal guinea pig. Starting on gestational day (GD) 2, pregnant guinea pigs received one of the following oral treatments up to and including GD 62 (term, about GD 68): 4 g ethanol.kg maternal body weight-1.day-1; isocaloric sucrose and pair-feeding; or water. Maternal blood ethanol concentration was determined at 1 h after the daily ethanol dose on GD 59. Fetuses were studied at GD 63 (mature, near-term fetus). Fetal body weight and brain weight were determined. The density (Bmax) and affinity (Kd) of the glutamate and NMDA binding sites in the fetal hippocampus were measured using a radioligand membrane binding assay; saturation analysis was conducted on hippocampal synaptic membrane preparation (HSMP). Maternal blood ethanol concentration on GD 59 was 269 +/- 111 (SD) mg/dl (59 +/- 24 mM). There was no maternal or embryonic fetal lethality in any of the three treatment groups, and ethanol treatment did not affect maternal body weight gain compared with sucrose or water treatment. Fetal brain weight, but not body weight, was d...Continue Reading

References

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Citations

May 31, 2002·Brain Research. Developmental Brain Research·Frederick P BellingerPeter A Wilce
Dec 14, 2002·Brain Research. Developmental Brain Research·Kimberly NixonSteven W Leslie
Apr 29, 1998·Brain Research. Developmental Brain Research·K A Kimura, J F Brien
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Aug 4, 2001·Neurotoxicology and Teratology·M L ByrnesJ F Brien
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May 31, 2003·Canadian Journal of Physiology and Pharmacology·Tara N McGoeyJames F Brien
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Feb 26, 2016·Neuroscience and Biobehavioral Reviews·Christine J FontaineBrian R Christie
Dec 15, 2004·Alcoholism, Clinical and Experimental Research·Rafael GalindoDaniel D Savage
Nov 27, 2008·Alcoholism, Clinical and Experimental Research·Theresa W GauthierLou Ann S Brown
Dec 3, 2009·Alcoholism, Clinical and Experimental Research·Sabrina L Samudio-RuizKevin K Caldwell
Jan 26, 2007·Alcoholism, Clinical and Experimental Research·Xiao-Du PingTheresa W Gauthier
Dec 9, 1998·Journal of Biomedical Science·G Tsai

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