Effect of chronic myocardial infarction on vagal cardiopulmonary baroreflex

Circulation Research
A J Minisi, M D Thames

Abstract

Sensory endings in the left ventricle are damaged by acute myocardial infarction. The goal of our experiments was to determine whether reflexes that originate in the heart are impaired by chronic myocardial infarction. Inferoposterior (n = 11) or anterior (n = 10) infarction was produced in dogs by ligation and intracoronary injection of rapidly hardening latex into either the proximal left anterior descending or left circumflex coronary arteries. Four weeks after infarction, the changes in renal sympathetic nerve activity induced by phenylephrine infusion, hemorrhage, and volume expansion were assessed before and after sinoaortic baroreceptor denervation. The results in infarct dogs were compared with the results in 11 sham-operated dogs. With arterial baroreceptors intact, baroreflex sensitivity (defined as the percent change in renal nerve activity per millimeter of mercury change in mean pulmonary artery wedge pressure) was similar in all groups of dogs. Following sinoaortic denervation, dogs with anterior and inferoposterior infarction had impaired responses to volume expansion. The responses during hemorrhage were abolished in dogs with inferoposterior infarction. We conclude that chronic myocardial infarction impairs ref...Continue Reading

References

Jan 1, 1979·Reviews of Physiology, Biochemistry and Pharmacology·P Thorén
Jul 1, 1979·British Heart Journal·F Perez-GomezA Garcia Aguado
Sep 1, 1977·British Heart Journal·F Perez-Gomez, A Garcia-Aguado
Jul 8, 1972·British Medical Journal·S W WebbJ F Pantridge
Dec 1, 1974·The Journal of Clinical Investigation·D L EckbergF M Abboud
May 1, 1973·The Journal of Clinical Investigation·A L MarkP G Schmid
May 1, 1973·Acta Physiologica Scandinavica·B Oberg, P Thorén
May 1, 1974·The American Journal of Physiology·Y Uchida, S Murao
Jan 1, 1970·The American Journal of Physiology·M D Thames, H A Kontos
Jun 1, 1972·Acta Physiologica Scandinavica·B Oberg, P Thorén
Feb 1, 1982·Acta Physiologica Scandinavica·A C EricsonH R Ulfendahl
May 1, 1981·Acta Physiologica Scandinavica·R A Little, B Oberg
Feb 1, 1963·The American Journal of Cardiology·L COSTANTIN

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Citations

Oct 1, 1993·Journal of the American College of Cardiology·J S Floras
Apr 4, 1998·The American Journal of Cardiology·S N PsychariD T Kremastinos
Aug 4, 2001·Autonomic Neuroscience : Basic & Clinical·H V Huikuri, T H Mäkikallio
Apr 1, 1995·Journal of Internal Medicine·H V Huikuri
Dec 26, 2006·Autonomic Neuroscience : Basic & Clinical·J E de C LacerdaE M Krieger
Jul 25, 2009·Journal of the American College of Cardiology·John S Floras
Apr 1, 1992·The American Journal of Cardiology·G GrassiG Mancia
Jun 17, 2008·Autonomic Neuroscience : Basic & Clinical·Christine M JonesAnthony J Minisi
Mar 16, 2018·Physiotherapy Research International : the Journal for Researchers and Clinicians in Physical Therapy·Elie FiogbéMarlene Aparecida Moreno
Feb 3, 2016·Journal of Physical Therapy Science·Tadasu OhshigeAkihisa Takamori

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