Effect of chronic nitrate treatment on retinal vessel caliber in open-angle glaucoma

American Journal of Ophthalmology
J E GrunwaldE B Dreyer

Abstract

A recent report has suggested that nitrate therapy may delay the progression of glaucomatous damage. To investigate the mechanism that may mediate this effect, we sought to determine whether nitrate therapy is associated with retinal vasodilatation in patients with glaucoma. Retinal venous and arterial diameters were determined from color fundus photographs of the optic nerve head obtained during a retrospective study designed to investigate any potential effects of chronic nitrate treatment on the progression of glaucomatous pathology. Fourteen eyes of 14 patients who were receiving chronic nitrate therapy for systemic diseases unrelated to glaucoma were randomly selected. Vascular measurements were compared with those of 15 eyes of 15 control patients with glaucoma who did not receive any nitrate therapy. In comparison with control patients, nitrate-treated patients showed significant average vasodilatation of 17% (P = .008) and 13% (P = .01) in the superior and inferior temporal retinal veins, respectively. A 5% increase in average retinal arterial diameter was also detected, but this was not statistically significant. Chronic nitrate treatment is associated with retinal venous dilatation in patients with glaucoma. Although ...Continue Reading

References

Sep 19, 1992·BMJ : British Medical Journal·V PatelE Kohner
May 1, 1990·Diabetes·J E GrunwaldC E Riva
Aug 15, 1988·American Journal of Ophthalmology·C A WilsonF L Ferris
Jul 1, 1986·Archives of Ophthalmology·J E GrunwaldB L Petrig
May 1, 1969·Diabetes·F SkovborgO Hartkopp
Feb 1, 1983·Archives of Ophthalmology·A YoshidaJ W McMeel
May 1, 1982·Archives of Ophthalmology·N P BlairJ W McMeel
Jun 1, 1995·American Journal of Ophthalmology·P A NetlandL J Hart
Oct 1, 1994·Cardiovascular Drugs and Therapy·K E Torfgård, J Ahlner
May 30, 1996·The American Journal of Cardiology·U Elkayam
May 1, 1965·Archives of Ophthalmology·R FRAYSER, J B HICKAM

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Citations

Jul 28, 1999·European Journal of Pharmacology·M C Koss
Jul 23, 1999·Survey of Ophthalmology·S OrgülJ Flammer
Jun 1, 2001·American Journal of Ophthalmology·J E GrunwaldJ Dupont
Sep 30, 2015·Medical Hypotheses·Wenjia Xie
May 31, 2002·American Journal of Ophthalmology·Juan E GrunwaldLili Grunwald
Apr 16, 2002·Acta Ophthalmologica Scandinavica·Hanna KotikoskiEsko Aine
Feb 13, 2003·Eye·K PolakL Schmetterer
Feb 24, 2001·International Ophthalmology Clinics·R H Farkas, C L Grosskreutz
Nov 14, 2019·Antioxidants·Antolin CantóMaría Miranda
Jun 28, 2021·Survey of Ophthalmology·Supriya AroraJay Chhablani
Jul 14, 2021·Investigative Ophthalmology & Visual Science·Thomas LawlerUNKNOWN Carotenoids in Age-Related Eye Disease Study Investigators

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