Effect of chronic poisoning with aluminum on the renal handling of phosphate in the rat

Toxicology Letters
S Mahieu, M L Calvo

Abstract

The effects of aluminum on renal function and phosphate handling were studied using clearance techniques in chronically-intoxicated rats. Rats were given aluminum hydroxide (80 mg/kg b.w., i.p.), three times per week during 6 months. The phosphate tubular transport capacity was evaluated by determining the maximum tubular transport (TmRPi) and the fractional excretion of phosphate (FE% Pi) during the infusion of phosphate solutions with increasing concentrations (0, 9, 18, 33 mM). Parathyroid gland function was studied using indirect methods: calcemia recovery after EDTA administration and the nephrogenic excretion of cAMP as indicative of renal PTH actions, by RIA. The systemic acid base status was determined and food intake and rat growth were controlled in both groups. No changes were observed in the renal function. Pi reabsorption values per ml glomerular filtration rate (TRPi/GFR microg/ml) for different Pi plasmatic concentrations were distributed following a saturation curve compatible with a saturation kinetics. Aluminum increased TmRPi/GFR in treated animals (T) 76+/-4 as compared with control animals (C) 57+/-7 microg/ml, without a statistical modification in the apparent affinity. The FE% Pi and FE% Na were significa...Continue Reading

References

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Citations

May 4, 2011·Biological Trace Element Research·María del Carmen ContiniStella Mahieu
Jan 22, 2000·Toxicology Letters·S MahieuM M Elias
Dec 22, 2007·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Daniel KrewskiVirginie Rondeau
Jun 29, 2004·Archives of Toxicology·Stella T MahieuMaría Mónica Elías
Jun 23, 2009·Toxicology Letters·Stella MahieuNéstor Millen
Jan 4, 2013·Toxicology and Industrial Health·Sayed M Rawy, Fatma M Seif Al Nassr
Nov 24, 2017·Dalton Transactions : an International Journal of Inorganic Chemistry·Matteo LariBegoña García

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