PMID: 41213Sep 1, 1979

Effect of chronic reserpine administration on K+ and amylase release from the rat parotid gland

Pediatric Research
J R MartinezC Cooper

Abstract

After chronic administration of reserpine, slices of the rat parotid gland incubated in vitro were found to release significantly more K+ and significantly less amylase than similar slices from untreated control animals. The extent of K+ release in the gland slices of the drug-treated animals shows no dependency on external Na+ or Ca++ and is probably enhanced because of a decreased activation of K+ uptake by the Na+-K+ pump. This effect may also involve a defective generation of cyclic GMP, which was found to enhance K+ uptake and, thus, to inhibit K+ release in control slices. The inhibition of amylase release observed after treatment with reserpine most likely results from a deficient level or utilization of the energy or nucleotide sources required for enzyme secretion, because a similar inhibition was observed in control slices after incubation in the absence of the purines inosine and adenine. These results indicate that chronic reserpine administration impairs the stimulus-secretion coupling mechanism in the rat parotid gland and results in abnormal responses from both alpha and beta adrenergic receptors.

Citations

Jan 1, 1987·General Pharmacology·N Adham, D Templeton
Dec 1, 1984·Experimental and Molecular Pathology·R M Müller, G M Roomans
Mar 1, 1987·Bioscience Reports·M A McPherson, R L Dormer
Feb 1, 1984·Journal of Dental Research·E WatsonH Horwitz

Related Concepts

Adrenergic beta-Agonists
Amylases
Calcium
Medihaler-Epi
Novodrin
Ouabain
Parotid Gland
Potassium
Norepinephrine Receptors
V-Serp

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