Effect of chronic sleep restriction and aging on calcium signaling and apoptosis in the hippocampus of young and aged animals

Progress in Neuro-psychopharmacology & Biological Psychiatry
Luciane de SouzaSergio Tufik

Abstract

Aging leads to progressive deterioration of physiological function and diminished responses to environmental stress. Organic and functional alterations are frequently observed in elderly subjects. Although chronic sleep loss is observed during senescence, little is known about the impact of insufficient sleep on cellular function in aging neurons. Disruption of neuronal calcium (Ca²⁺) signaling is related to impaired neuronal function and cell death. It has been hypothesized that sleep deprivation may compromise neuronal stability and induce cell death in young neurons; however, it is necessary to evaluate the impact of aging on this process. Therefore, the aim of this study was to evaluate the effects of chronic sleep restriction (CSR) on Ca²⁺ signaling and cell death in the hippocampus of young and aged animals. We found that glutamate and carbonyl cyanide-p-trifluoromethoxyphenylhydrazone (FCCP) induced a greater elevation in cytosolic Ca²⁺ ([Ca²⁺](c)) in hippocampal slices from aged rats subjected to CSR compared to age-matched controls. Interestingly, aged-matched controls showed a reduced Ca²⁺ response to glutamate and FCCP, relative to both CSR and control young animals. Apoptotic nuclei were observed in aged rats from b...Continue Reading

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Citations

Apr 7, 2017·Neuron·Bryce A ManderMatthew P Walker
Aug 11, 2020·Sleep Disorders·Montserrat Melgarejo-GutiérrezJuan Carlos Rodríguez-Alba
May 1, 2018·Frontiers in Aging Neuroscience·Matthew W SchelkeRichard S Isaacson
Dec 25, 2019·Evidence-based Complementary and Alternative Medicine : ECAM·Juan LiGang Chen

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