Abstract
Tetrahydrobiopterin (BH4) is a key cofactor of nitric oxide (NO) synthase. Reduced BH4 levels may mediate endothelial NO synthase uncoupling, resulting in reduced NO synthesis and enhanced oxidative stress. In rats after 5/6 nephrectomy (Nx), administration of BH4 prevents the onset of hypertension, typically observed 10 days after Nx. This effect is associated with an increased synthesis of NO. The aim of the present study was to evaluate the effect of chronic BH4 therapy on blood pressure and renal morphology. During an 8 week period, five groups of rats were studied: untreated 5/6 Nx rats, BH4-treated Nx rats (BH4, 10 mg/kg body weight/day administered intraperitoneally), l-arginine treated Nx rats (LA, 130 mg/kg/day), diltiazem-treated Nx rats (DILT, 30 mg/kg/day) and sham-operated rats. Treatments were commenced 24 h after surgery. Systolic blood pressure values (SBP), 24 h proteinuria (UP) and creatinine clearance rate (CCR) were assessed before and at weeks 4 and 8 of the study period. Histological changes in the kidney were evaluated at the end of the study (week 8). Compared with baseline, in Nx rats both SBP and UP increased significantly (112+/-1 to 136+/- 1.4 mmHg, P<0.01 and 23+/-2 to 127 +/- 26 mg/day, P<0.01, res...Continue Reading
References
Jun 1, 1995·Kidney International·I AshabA Iaina
Mar 1, 1994·Journal of the American Society of Nephrology : JASN·T KatohK F Badr
Jan 1, 1993·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·E PodjarnyJ Bernheim
Jan 1, 1997·The Journal of Clinical Investigation·E StroesT Rabelink
Jul 1, 1997·Kidney International·S AielloG Remuzzi
Jun 2, 1998·Kidney International·N D VaziriY Ding
Oct 17, 1998·Hypertension·Z NiN D Vaziri
Feb 10, 2000·Circulation Research·T HeitzerT Münzel
Sep 29, 2000·Circulation Research·K ShinozakiA Kashiwagi
Mar 29, 2001·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Y DumontR Larivière
May 30, 2001·Transplantation Proceedings·A D'AmbrosioF Quintieri
Nov 17, 2001·Hypertension·H J HongM H Yen
Feb 19, 2002·Kidney International·Galit HasdanMauro Rathaus
May 11, 2002·Current Drug Metabolism·A C F Gorren, B Mayer
Dec 11, 2002·Kidney International·Nosratola D VaziriRam K Sindhu
Jun 14, 2003·Nephron. Physiology·Eduardo PodjarnyJacques Bernheim
Oct 22, 2003·Journal of the American Society of Nephrology : JASN·Marcin AdamczakEberhard Ritz
Citations
Mar 28, 2008·Current Hypertension Reports·Muhiddin A Ozkor, Arshed A Quyyumi
Jun 4, 2011·Cardiology Research and Practice·Christopher R Martens, David G Edwards
Mar 5, 2008·Nephrology·Monica G Arellano MendozaBruno Escalante
Jul 11, 2006·Medical Hypotheses·Mark F McCarty
Jun 13, 2012·Renal Failure·Xiaofang YuXiaoqiang Ding
Feb 27, 2010·American Journal of Hypertension·Mya ThidaYi Zhang
May 26, 2017·PloS One·Basma IsmailJean N DaSilva
Apr 7, 2007·Journal of Cardiovascular Pharmacology·Kohei YamamizuTomio Okamura
Dec 16, 2006·The Journal of Clinical Hypertension·Matthias HermannThomas F Lüscher
Aug 19, 2007·Clinical Journal of the American Society of Nephrology : CJASN·Sofia B AhmedNorman K Hollenberg
Dec 6, 2014·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Jeanie ParkArshed A Quyyumi
Jun 2, 2006·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Anwar Y DunbarYoichi Osawa
May 4, 2012·American Journal of Physiology. Renal Physiology·Idit F SchwartzDoron Schwartz
Mar 11, 2016·American Journal of Physiology. Renal Physiology·Ann M LinJeanie Park
Sep 5, 2018·International Journal of Molecular Sciences·Ashfaq AhmadJoseph K Ritter
Nov 11, 2020·PLoS Biology·Mahmoud H ElbatreekHarald H H W Schmidt
Apr 4, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Natalia A ShnayderRegina F Nasyrova