Effect of chronic treatment with morphine, midazolam, and both together on beta-endorphin levels in the rat

Brain Research Bulletin
A K Rattan, G A Tejwani

Abstract

We have recently reported that a short-acting anesthetic and analgesic drug midazolam can produce analgesia and decrease morphine tolerance and dependence in the rat by interacting with the opioid system. This study was designed to investigate the effect of midazolam, morphine, and both together on beta-endorphin levels in the rat. Male Sprague-Dawley rats were divided into four groups: (1) saline-saline; (2) saline-morphine; (3) midazolam-saline, and (4) midazolam-morphine groups. First, saline or midazolam injection was given IP and after 30 min a second injection of saline or morphine was given subcutaneously once daily for 11 days. Animals were sacrificed on 11th day 60 min after the last injection, to measure beta-endorphin by radioimmunoassay. Saline-morphine-treated animals showed a significant increase in beta-endorphin levels in the cortex, pons, medulla, lumbar spinal cord, adrenals, and spleen, and a decrease only in its level in pituitary. Midazolam-saline-treated animals showed a significant increase in beta-endorphin levels only in the medulla, and a decrease in its levels in hippocampus, striatum, and adrenals. Saline-morphine-treated animals did not show any changes in plasma beta-endorphin, but animals treated ...Continue Reading

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Citations

Mar 3, 2005·Pharmacology, Biochemistry, and Behavior·Jun-Li CaoYin-Ming Zeng
May 2, 2001·Biochemical Pharmacology·M SandriniS Candeletti
Jan 1, 1997·Peptides·G A OlsonA J Kastin
Jan 27, 1998·Brain Research Bulletin·D N ZhuT Ogihara
Apr 10, 2012·Neuropeptides·K P GudehithluM Hadjiconstantinou
Sep 17, 2005·Peptides·Xiaoying WangRichard B Rothman
Jan 27, 2009·Journal of the Neurological Sciences·Arthur S WaltersWeidong Le

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