May 1, 1977

Effect of chronic treatment with propranolol on blood pressure and cardiovascular reactivity in spontaneously hypertensive rats

Archives Internationales De Pharmacodynamie Et De Thérapie
T KuboK Ennvu

Abstract

Young SHR were treated with propranolol (16 or 64 mg/kg per day) from 6 up to 14 weeks of age. Systolic blood pressure was significantly lower in SHR treated with propranolol (64 mg/kg) than in untreated SHR; no effect was seen in SHR treated with 16 mg/kg. The hemodynamic characteristics of the hindquarter vascular beds did not significantly differ between untreated and propranolol-treated SHR. Adult SHR were given propranolol (64 mg/kg per day) from 5 up to 8 months of age. Moderate reduction of systolic blood pressure was observed from 2 to 3 months of propranolol treatment. The cardiovascular pressor response to noradrenaline decreased in propranolol-treated SHR, while the decreased responsiveness was not found after pithing.

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Mentioned in this Paper

Rats, Inbred SHR
Systolic Blood Pressure Measurement
Blood Vessel
August Rats
Diastolic Blood Pressure
Regional Blood Flow
Norepinephrine, (+, -)-Isomer
Hydroxydopamine
Pulmonary Vascular Resistance
Norepinephrine

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