PMID: 9435590Jan 22, 1998Paper

Effect of chronic volume overload on baroreflex control of heart rate and sympathetic nerve activity

The American Journal of Physiology
R WillenbrockR Dietz

Abstract

Baroreceptor-heart rate reflex sensitivity is decreased in congestive heart failure. The reflex control of heart rate and sympathetic nerve activity in rats with chronic volume overload, an established model for moderate heart failure, is still unknown. Therefore, we investigated the regulation of humoral and neuronal sympathetic activity and the baroreflex control of heart rate and sympathetic nerve activity in conscious, unrestrained rats with aortocaval shunt. Rats with aortocaval shunts had larger hearts (388 +/- 11 vs. 277 +/- 4 mg/100 g body wt), elevated central venous pressures (14 +/- 4 vs. 4 +/- 3 mmHg), and higher atrial natriuretic peptide plasma levels (87 +/- 16 vs. 25 +/- 3 pmol/l) than controls but had similar systemic blood pressure and heart rate values. Plasma epinephrine (0.63 +/- 0.16 vs. 0.21 +/- 0.08 pmol/l, P < 0.05) and norepinephrine concentrations (0.27 +/- 0.03 vs. 0.16 +/- 0.02 pmol/l, P < 0.05) were elevated in shunted rats compared with controls. Nitroprusside-induced hypotension led to a significantly greater increase in efferent splanchnic sympathetic nerve activity in shunted rats than in controls (0.9 +/- 0.1 vs. 2.6 +/- 0.6 microV, P < 0.05), whereas the heart rate responses were not differen...Continue Reading

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Citations

Nov 22, 2000·American Journal of Physiology. Heart and Circulatory Physiology·H YamakawaT Eto
Mar 1, 2005·American Journal of Physiology. Heart and Circulatory Physiology·Xi WangNaranjan S Dhalla
Apr 10, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Melissa R DentParamjit S Tappia
Jan 19, 2016·BioMed Research International·David C AndradeRodrigo Del Rio
Jun 21, 2008·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Erica A WehrweinDavid L Kreulen

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