PMID: 8941521Nov 1, 1996Paper

Effect of cigarette smoke extract on arteriolar dilatation in vivo

Journal of Applied Physiology
W G Mayhan, G M Sharpe

Abstract

The goal of this study was to determine whether cigarette smoke extract alters dilatation of arterioles in vivo in response to agonists that produce activation of ATP-sensitive potassium channels and activation of adenylate cyclase. By using intravital microscopy, we measured diameter of arterioles contained within the microcirculation of the hamster cheek pouch during suffusion with agonists in the absence and presence of cigarette smoke extract (0.1, 0.5, and 1.0%). Before treatment with cigarette smoke extract, activation of ATP-sensitive potassium channels with aprikalim and cromakalim produced dose-related dilatation of cheek pouch arterioles. Similarly, activation of adenylate cyclase with isoproterenol and forskolin produced dose-related dilatation of cheek pouch arterioles before treatment with cigarette smoke extract. Superfusion of 0.1% cigarette smoke extract did not change baseline diameter of arterioles and did not alter responses of cheek pouch arterioles to activation of ATP-sensitive potassium channels and adenylate cyclase. Superfusion of 0.5 and 1.0% cigarette smoke extract also did not alter baseline diameter of arterioles but did impair dilatation of arterioles in response to activation of ATP-sensitive pota...Continue Reading

References

May 1, 1976·Atherosclerosis·J P Strong, M L Richards
Jan 1, 1992·Journal of Cardiovascular Pharmacology·C Rångemark, A Wennmalm
Nov 1, 1992·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·S J LinS Chien
Nov 1, 1992·Scandinavian Journal of Clinical and Laboratory Investigation·E W JensenN J Christensen
Jan 1, 1992·Experimental Physiology·N B Standen
Mar 1, 1992·The Medical Clinics of North America·P E McBride
Feb 1, 1992·Journal of Applied Physiology·C A HalesM Witten
Mar 1, 1992·The Journal of Hand Surgery·L N van AdrichemJ C van der Meulen
Jan 1, 1992·British Journal of Plastic Surgery·L N van AdrichemJ C van der Meulen
Jan 1, 1991·Neuroepidemiology·M Higa, Z Davanipour
Feb 1, 1991·Stroke; a Journal of Cerebral Circulation·T NagaoM Fujishima
Jul 1, 1990·The American Journal of Physiology·M T NelsonN B Standen
May 1, 1990·Journal of Applied Physiology·R E BarrowD N Herndon
Apr 1, 1989·Journal of Applied Physiology·G D LeikaufH E Wey
Nov 1, 1989·Pflügers Archiv : European journal of physiology·M Wahl
Jan 1, 1989·Journal of Applied Physiology·W E HoldenM R Malinow
Jan 1, 1988·Trends in Pharmacological Sciences·N S Cook
Mar 1, 1988·Journal of Applied Physiology·C A HalesJ Burke
Mar 1, 1981·American Heart Journal·W B Kannel
Jul 1, 1994·The British Journal of Surgery·D J HigmanJ T Powell
Sep 21, 1993·European Journal of Pharmacology·W G Mayhan
Oct 1, 1993·The British Journal of Surgery·D J HigmanJ T Powell
Jul 1, 1993·Journal of Applied Physiology·W G Mayhan, I Rubinstein

❮ Previous
Next ❯

Citations

Apr 26, 2002·Journal of Cardiovascular Pharmacology·William G Mayhan, Glenda M Sharpe
Oct 22, 2002·American Journal of Physiology. Heart and Circulatory Physiology·Qin FangWilliam G Mayhan
Nov 4, 2008·Platelets·Anna Rita TognaGiuseppina I Togna
Nov 13, 2013·Current Eye Research·Fatih UlaşSerdal Çelebi
May 25, 2016·Clinical Science·Victoria AustinRoss Vlahos
Sep 23, 2008·Journal of Cardiovascular Pharmacology·J F ArgachaG Berkenboom
Oct 28, 2006·The Journal of Pharmacology and Experimental Therapeutics·DaLiao XiaoLubo Zhang
Jan 6, 2009·Reviews on Environmental Health·Timothy E O'TooleAruni Bhatnagar
Feb 10, 2009·Circulation Journal : Official Journal of the Japanese Circulation Society·Nicoline JochmannVerena Stangl
Aug 16, 2017·Oxidative Medicine and Cellular Longevity·Abdullah KaplanFouad A Zouein
Jan 1, 2020·Journal of Diabetes and Metabolic Disorders·Mehdi EbrahimiRamin Heshmat
Mar 21, 2020·Biomolecules·Ryuta MikawaMasataka Sugimoto
Dec 5, 2006·Atherosclerosis·Astrid SchmiederDavid Bernhard

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.