Effect of cigarette smoke on esophageal epithelium of the rabbit

Gastroenterology
R C OrlandoD W Powell

Abstract

Cigarette smoking is a recognized risk factor for esophageal mucosal disease. For this reason we investigated the effects of smoke on esophageal epithelial electrolyte transport and barrier function in the rabbit. Studies were performed using an extract of cigarette smoke (EOCS) prepared from high-tar, high-nicotine cigarettes. Epithelia were exposed to EOCS in vivo or in vitro in the Ussing chamber. Acute in vivo exposure to EOCS lowered in vivo esophageal potential difference by 61%, and in vitro studies established that this was due to inhibition of active Na transport from mucosa to serosa. Exposure to an EOCS had no effect on net Cl transport or epithelial permeability, the latter reflected by the absence of change in electrical resistance or mannitol flux. The ability of an EOCS to lower potential difference (and inhibit Na transport) was dose-related and equally effective whether contact occurred with the luminal or serosal surface of the tissue. Similar studies performed with an EOCS prepared from filtered smoke established that the component(s) in EOCS responsible for the effects on transport resided in the particulate phase of smoke (i.e., nicotine and "tars"). However, nicotine only inhibited Na transport from the se...Continue Reading

Citations

Nov 6, 2004·Alimentary Pharmacology & Therapeutics·D O CastellR Arnold
Oct 7, 2010·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Canan Bor-CaymazRoy C Orlando
Aug 14, 2013·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·R Farré
Apr 3, 2007·Southern Medical Journal·Alan C Moss, Ciarán P Kelly
Nov 27, 2008·Journal of Gastroenterology and Hepatology·Serhat Bor, Doga Capanoglu
Jun 25, 2009·The American Journal of Gastroenterology·Kulwinder S DuaReza Shaker
Apr 14, 2007·American Journal of Physiology. Gastrointestinal and Liver Physiology·N A TobeyR C Orlando
Nov 1, 1988·Journal of Dental Research·N A TobeyR C Orlando
Nov 1, 1996·Digestive Diseases and Sciences·S C KadakiaR T Shaffer
May 1, 1993·Comparative Biochemistry and Physiology. Comparative Physiology·G GäbelH Martens
Jan 20, 2005·The Medical Clinics of North America·Roy C Orlando

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