Effect of cigarette smoke on ethanol-induced gastric mucosal lesions: the role of nitric oxide and neutrophils

European Journal of Pharmacology
J Y ChowC H Cho

Abstract

The roles of neutrophil aggregation, inducible nitric oxide synthase activation and chemoattractant, leukotriene B4, in potentiation of the cigarette smoke effect on ethanol-induced gastric mucosal damage were studied. Smoke exposure markedly increased gastric lesion formation following ethanol administration and this was accompanied by substantial increase in gastric mucosal leukotriene B4 concentration, myeloperoxidase and inducible nitric oxide synthase activities. Antineutrophil serum or aminoguanidine pretreatment significantly attenuated both gastric mucosal lesion formation and inducible nitric oxide synthase activity. The increased myeloperoxidase activity was abolished by antineutrophil serum but not by aminoguanidine. These data indicated that both neutrophil mobilization and inducible nitric oxide synthase activation in the gastric mucosa play an important role in the potentiating action of cigarette smoke on ethanol-induced gastric mucosal lesion formation. Increased synthesis of nitric oxide from inducible nitric oxide synthase during gastric damage may be secondary to neutrophil infiltration in the gastric mucosa. Chemoattractant leukotriene B4 could also contribute to neutrophil recruitment in the tissue.

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Citations

Oct 12, 2001·Journal of Physiology, Paris·C H Cho
Dec 10, 2002·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·M GottelandO Brunser
Oct 5, 2007·Journal of Gastroenterology and Hepatology·Eman El EterMaha Arafa
Mar 12, 2009·The Journal of Pharmacology and Experimental Therapeutics·Yueming TangAli Keshavarzian
Aug 26, 2009·World Journal of Gastroenterology : WJG·Muna HammadiSherif M Karam
May 16, 2014·Life Sciences·L LuC H Cho
Apr 17, 2008·British Journal of Pharmacology·V SibiliaC Netti
Apr 25, 2009·Alcoholism, Clinical and Experimental Research·Yueming TangAli Keshavarzian
Jun 17, 2015·Experimental Physiology·Soad Shaker AliMansour Ibrahem Suliman
May 29, 2001·Microscopy Research and Technique·S CalatayudJ V Esplugues
Jul 12, 2001·American Journal of Physiology. Gastrointestinal and Liver Physiology·W P WangC H Cho

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