PMID: 8587374Jan 1, 1995Paper

Effect of cigarette smoking and nicotine on plasma endothelin-1 levels

Journal of Cardiovascular Pharmacology
S GoerreT F Lüscher

Abstract

Although cigarette smoking is an established risk factor for atherosclerosis, the true mediator of vessel diseases associated with smoking is not known. Because endothelin-1 (ET-1) exhibits potent vasoconstrictor activity, it may act as a mediator in this condition. We determined venous ET-1 and nicotine levels in 12 smokers (age 21-24 years, 2-52 pack-years) before and 10 min, 4 h, and 8 h after the beginning of smoking. To distinguish an isolated effect of nicotine, 11 nonsmokers (age 24-50 years) were investigated while they were wearing a transdermal nicotine delivery system (TNDS). ET-1 was measured by RIA and nicotine by HPLC. Baseline ET-1 plasma levels before the exposure to either smoking or nicotine administration were comparable in smokers (1.07 +/- 0.3 pg/ml) and in nonsmokers (1.04 +/- 0.3 pg/ml). Smokers had borderline significantly higher ET-1 plasma levels within 10 min after the onset of smoking (1.3 +/- 0.3 pg/ml vs. 1.08 +/- 0.3 pg/ml; p = 0.055) but not after 4 and 8 h. Nonsmokers exposed to TNDS did not exhibit any significant plasma ET-1 changes. We conclude that the increase in plasma ET-1 after cigarette smoking is of borderline significance and is a transitory phenomenon restricted to the first 10 min a...Continue Reading

Citations

Mar 12, 2004·Transplantation Proceedings·A YavuzG Yakupoğlu
May 24, 2000·European Journal of Pharmacology·J E Tanus-SantosH Moreno
Sep 6, 2000·International Journal of Experimental Pathology·R Michael Pittilo
Jul 10, 2004·American Journal of Respiratory Cell and Molecular Biology·Joanne L WrightAndrew Churg
Jan 18, 2003·Current Hypertension Reports·Robert D BrookSanjay Rajagopalan
Jan 20, 2005·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Barbara WimpissingerKaija Polak
Mar 31, 2000·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·M RegaladoD E Wesson
May 20, 2003·Journal of Periodontal Research·Daisuke FujiokaHidemi Kurihara
Jul 5, 2015·Metabolism: Clinical and Experimental·Alexandra B CookeStella S Daskalopoulou
Jul 5, 2005·Expert Opinion on Investigational Drugs·M A KhanD P Mikhailidis
Aug 7, 2002·Acta Physiologica Hungarica·E OzanS Ozan
Jul 7, 2001·Pulmonary Pharmacology & Therapeutics·M SofiaL Carratù
Dec 3, 1999·Prostaglandins, Leukotrienes, and Essential Fatty Acids·L Y Lee, J L Hong

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