PMID: 11316128Apr 24, 2001Paper

Effect of cilnidipine on left ventricular diastolic function in hypertensive patients as assessed by pulsed Doppler echocardiography and pulsed tissue Doppler imaging

Japanese Circulation Journal
Y OnoseS Ito

Abstract

The purpose of the present study was to examine the mechanisms of improvement in left ventricular (LV) diastolic function in hypertensive patients treated with cilnidipine, a new and unique calcium antagonist that has both L-type and N-type voltage-dependent calcium channel blocking actions, using pulsed Doppler echocardiography and pulsed tissue Doppler imaging. The study comprised 35 untreated patients with essential hypertension (19 men and 16 women; mean age 65+/-10 years). The peak early diastolic and atrial systolic transmitral flow velocities (E and A, respectively) and their ratio (E/A), and the peak early diastolic and atrial systolic motion velocities (Ew and Aw, respectively) of the LV posterior wall and their ratio (Ew/Aw) were determined in all patients before and after 1, 3 and 6 months on cilnidipine (10 mg/day). One month: Systolic and diastolic blood pressures were significantly decreased. E and E/A were significantly increased, whereas there were no significant changes in Ew and Ew/Aw. Three months: Ew and Ew/Aw were significantly increased compared to those before and 1 month after cilnidipine. Six months: E and E/A were significantly increased compared with before and 3 months after cilnidipine, and Ew and E...Continue Reading

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Citations

May 19, 2010·Biomarkers in Medicine·Martin UnverdorbenBernhard R Winkelmann
Jan 28, 2003·Circulation Journal : Official Journal of the Japanese Circulation Society·Jinyao LiuMasunori Matsuzaki
Aug 15, 2009·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Hiroshi ItoShin Takiuchi

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