Effect of cilostazol, a phosphodiesterase type III inhibitor, on histamine-induced increase in [Ca2+]i and force in middle cerebral artery of the rabbit

British Journal of Pharmacology
Y ShiraishiT Itoh

Abstract

1. The effect of cilostazol, an inhibitor of phosphodiesterase type III (PDE III), on the contraction induced by histamine was studied by making simultaneous measurements of isometric force and the intracellular concentration of Ca2+ ([Ca2+]i) in endothelium-denuded muscle strips from the peripheral part of the middle cerebral artery of the rabbit. 2. High K+ (80 mM) produced a phasic, followed by a tonic increase in both [Ca2+]i and force. Cilostazol (10 microM) did not modify the resting [Ca2+]i, but it did significantly decrease the tonic contraction induced by high K+ without a corresponding change in the [Ca2+]i response. 3. Histamine (3 microM) produced a phasic, followed by a tonic increase in both [Ca2+]i and force. Cilostazol (3 and 10 microM) significantly reduced both the phasic and tonic increases in [Ca2+]i and force induced by histamine, in a concentration-dependent manner. 4. Rp-adenosine-3':5'-cyclic monophosphorothioate (Rp-cAMPS, 0.1 mM), a PDE-resistant inhibitor of protein kinase A (and as such a cyclic AMP antagonist), did not modify the increases in [Ca2+]i and force induced by histamine alone, but it did significantly decrease the cilostazol-induced inhibition of the histamine-induced responses. 5. In Ca2...Continue Reading

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Citations

Feb 23, 2010·Journal of Anesthesia·Toshiyuki MinonishiYoshio Hatano
Mar 31, 2010·Neurological Research·Akio NishinoToshiki Yoshimine
Dec 31, 2004·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Steffen BirkJes Olesen
Jan 21, 2003·The Japanese Journal of Physiology·Yasuaki Yashiro, Toshio Ohhashi
Aug 13, 2010·Hypertension in Pregnancy : Official Journal of the International Society for the Study of Hypertension in Pregnancy·Tamao YamamotoTakashi Suzuki
Mar 29, 2013·The Journal of Pharmacology and Experimental Therapeutics·Kyoung In JungChan Kee Park
Oct 25, 2002·Cardiovascular Drug Reviews·Katsufumi MizushigeHitoshi Suzuki
Jun 14, 2000·American Journal of Physiology. Heart and Circulatory Physiology·N I Gokina, J A Bevan
Jun 14, 2000·American Journal of Physiology. Heart and Circulatory Physiology·N I Gokina, J A Bevan
Dec 12, 2001·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·K C LeeC R Jan

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