Effect of cilostazol, a selective type-III phosphodiesterase inhibitor, on water-immersion stress-induced gastric mucosal injury in rats

Journal of Gastroenterology
Reina OhbaSumio Watanabe

Abstract

Cilostazol, a specific type-III phosphodiesterase inhibitor, is widely used for the treatment of ischemic symptoms of peripheral vascular disease. Recent studies have reported that the mechanism of cilostazol is related to the suppression of pro-inflammatory cytokine production and improvement of local microcirculation disturbances. The pathogenesis of stress-induced gastric mucosal lesions is characterized by the activation of inflammatory cells and the production of inflammatory cytokines. The effects of cilostazol on the development of gastric mucosal lesions have not been reported. In the present study, we examined the effect of a cilostazol on water-immersion stress-induced gastric mucosal lesions. Rats were subjected to water-immersion stress with or without pretreatment with a single intraperitoneal injection of the selective type-III phosphodiesterase inhibitor, cilostazol. We measured the gastric mucosal lesion and the concentrations of myeloperoxidase (MPO), interleukin-1beta (IL-1beta), tumor necrosis factor-alpha (TNF-alpha), and cytokine-induced neutrophil chemoattractant-1 (GRO/CINC-1), as an index of neutrophil accumulation and pro-inflammatory cytokine production. Cilostazol ameliorated the gastric mucosal injur...Continue Reading

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Citations

Oct 17, 2007·Journal of Atherosclerosis and Thrombosis·Daisuke MoriMasayuki Yoshida
Oct 10, 2009·American Journal of Physiology. Gastrointestinal and Liver Physiology·Hisayuki MatsunagaSoichiro Miura
Sep 1, 2012·Scandinavian Journal of Gastroenterology·Masaaki HigashiyamaSoichiro Miura
May 20, 2020·Naunyn-Schmiedeberg's Archives of Pharmacology·Asmaa Mohamed Abdel-AzizSeham A Abdel-Gaber
Aug 3, 2019·Naunyn-Schmiedeberg's Archives of Pharmacology·Helmy MoawadMohammed A Alkhawlani

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