PMID: 4018640Aug 1, 1985Paper

Effect of cimetidine on gastric secretion and duodenogastric reflux

R J MelvilleM Hobsley


In 19 subjects (four controls, one gastric ulcer and 14 duodenal ulcer) maximal gastric secretion was evoked with histamine 0.13 mumol/kg/h (0.04 mg/kg/h) for two to two and a half hours. A slow intravenous bolus dose of 200 mg cimetidine was given at the beginning of the last hour. Gastric secretion was measured before and after cimetidine administration and expressed both as mean acid output (mmol H+/h) and 'pyloric loss and duodenogastric reflux corrected' volume (Vg, ml/h). Mean reduction by acid output was 86%; mean reduction by corrected volume (Vg) was only 64%. The discrepancy, which is significant (p less than 0.01), is caused by a marked increase in duodenogastric reflux after cimetidine.


Sep 18, 1976·British Medical Journal·R J BaileyR Williams
Oct 1, 1979·Agents and Actions·P F Whitfield, M Hobsley
Feb 21, 1970·British Medical Journal·M A Hassan, M Hobsley
Jul 1, 1970·Clinical Science·J R Gardham, M Hobsley

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Jun 1, 1995·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·A RühlM Wienbeck

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