Effect of cinnamtannin B-1 on cholecystokinin-8-evoked responses in mouse pancreatic acinar cells

Clinical and Experimental Pharmacology & Physiology
Ramon Rivera-BarrenoAntonio González

Abstract

1. Cinnamtannin B-1 is a naturally occurring A-type proanthocyanidin that belongs to a class of polyphenols widely distributed throughout the plant kingdom and exhibiting anti-oxidant properties. 2. In the present study, we examined the effects of cinnamtannin B-1 on cholecystokinin octapeptide (CCK-8)-evoked Ca(2+) mobilization, reactive oxygen species (ROS) production and amylase secretion in the exocrine pancreas. 3. Stimulation of cells with 1 nmol/L CCK-8 led to a transient increase in the cytosolic free calcium concentration ([Ca(2+) ](c) ), followed by a decrease towards a value close to the prestimulation level. In the presence of 10 μmol/L cinnamtannin B-1, stimulation of cells with CCK-8 resulted in a smaller [Ca(2+) ](c) peak response, a faster rate of decay of [Ca(2+) ](c) and lower values for the steady state of [Ca(2+) ](c) , compared with the effect of CCK-8 alone. Cinnamtannin B-1 decreased Ca(2+) influx after depletion of intracellular stores by either CCK-8 or thapsigargin (1 μmol/L). Conversely, CCK-8 increased the fluorescence of 5-(and-6)-chloromethyl-2',7'-dichlorodihydrofluorescein diacetate acetyl ester (CM-H(2) DCFDA), reflecting an increase in oxidation. Cinnamtannin B-1 reduced CCK-8-induced oxidation...Continue Reading

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Citations

Aug 2, 2013·Journal of Physiology and Biochemistry·Patricia Santofimia-CastañoAntonio González
Jul 30, 2014·Toxicology Letters·Patricia Santofimia-CastañoAntonio Gonzalez
Oct 21, 2011·Molecular and Cellular Biochemistry·Lourdes Garcia-SanchezAntonio Gonzalez
Aug 3, 2014·Molecular and Cellular Biochemistry·Patricia Santofimia-CastañoAntonio Gonzalez
Jun 26, 2020·Frontiers in Cell and Developmental Biology·Akito Maeda
May 13, 2014·Journal of Agricultural and Food Chemistry·Ting WangHeyao Wang
Jun 18, 2011·Brain Research·Patricia Santofimia-CastañoAntonio Gonzalez

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