PMID: 11903835Mar 21, 2002Paper

Effect of cisapride on gastric emptying in premature infants with feed intolerance

Journal of Paediatrics and Child Health
C P BarnettR Haslam

Abstract

To assess the effect of cisapride on gastric emptying and gastro-oesophageal reflux (GOR) symptoms in preterm infants with feed intolerance. Sixteen preterm infants (gestational age 24-35 weeks) with feed intolerance were enrolled in the study. Infants were randomized to receive 7 days of cisapride 0.2 mg/kg four times a day, immediately followed by 7 days of placebo or vice versa. Gastric emptying was measured using the [13C]-octanoic acid breath test prior to study entry and repeated on day 5, 6 or 7 after randomization and 5, 6 or 7 days after crossover. The symptoms of GOR were monitored during the study period using a standardized reflux chart. Weight was recorded daily. There was no change in gastric emptying in infants prescribed cisapride (gastric half-emptying time (t1/2) 31.9 +/- 4.7 vs 34.2 +/- 3.9 min for placebo vs cisapride, respectively; P = 0.65). Infants on cisapride had slower growth and there was no change in reflux symptoms. The use of cisapride in preterm infants with feed intolerance cannot be recommended.

Citations

May 26, 2005·Current Gastroenterology Reports·Sara Emerenziani, Daniel Sifrim
Oct 11, 2005·Acta Paediatrica. Supplement·Josef Neu, Liyan Zhang
Jan 13, 2015·Nutrients·Sourabh DuttaChristoph Fusch
Jan 24, 2009·Clinics in Perinatology·Neelesh A Tipnis, Sajani M Tipnis
Jan 21, 2015·Biopharmaceutics & Drug Disposition·Jennifer J BonnerTrevor N Johnson
Oct 13, 2006·Journal of Perinatology : Official Journal of the California Perinatal Association·H AlyN El-Badry
Apr 16, 2014·Journal of Pediatric Gastroenterology and Nutrition·Clara LootsTaher Omari
Aug 14, 2019·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Liz Febo-RodriguezRobert J Shulman
Apr 16, 2010·The Cochrane Database of Systematic Reviews·Suzanna MaclennanRuth E Gilbert

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