PMID: 11929392Apr 4, 2002Paper

Effect of cisapride on nocturnal transient lower oesophageal sphincter relaxations and nocturnal gastro-oesophageal reflux in patients with oesophagitis: a double-blind, placebo-controlled study

Alimentary Pharmacology & Therapeutics
N PehlivanovR McCallum

Abstract

To investigate the effect of cisapride, a selective 5-hydroxytryptamine-4 receptor agonist, on the frequency of nocturnal transient lower oesophageal sphincter relaxations and oesophageal acid exposure in patients with gastro-oesophageal reflux disease. In a double-blind, placebo-controlled study, 10 patients with gastro-oesophageal reflux disease (six male and four female; mean age, 54 +/- 10.4 years) were randomly assigned to 5-day treatments with cisapride, 10 mg q.d.s., or placebo, separated by a 2-day washout period before the treatment crossover. Sleep stages, lower oesophageal sphincter tone and oesophageal pH were monitored overnight at the end of each treatment regimen. Gastric emptying was assessed before treatment. Cisapride decreased the frequency of transient lower oesophageal sphincter relaxations during sleep (1.2 +/- 0.2/h vs. 2.7 +/- 0.5/h with placebo; P=0.004) and oesophageal acid exposure (17.2 +/- 9.9% with placebo vs. 7.2 +/- 4.2% with cisapride; P=0.4). Cisapride increased lower oesophageal sphincter tone from 12.7 +/- 2.8 mmHg with placebo to 16.9 +/- 3.9 mmHg (P=0.03), and decreased heartburn episodes and antacid consumption. All patients had normal gastric retention data over 4 h. In patients with gast...Continue Reading

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Citations

Apr 25, 2006·Journal of Clinical Gastroenterology·Yu Kyung ChoIn-Sik Chung
Apr 23, 2010·Expert Opinion on Investigational Drugs·Noriaki ManabeMichael Camilleri
Aug 20, 2011·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Yukie SatouShuhei Yamaguchi
Oct 28, 2011·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·C HempflingJ Wörl
Feb 24, 2012·Alimentary Pharmacology & Therapeutics·J TackV Stanghellini
May 28, 2011·Journal of Digestive Diseases·Eamonn M M Quigley
Jul 25, 2014·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·J BroadG J Sanger

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