Effect of cisplatin chemotherapy on extracortical tissue formation in canine diaphyseal segmental replacement

Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society
D R YoungE Y Chao

Abstract

The reconstruction of large bone and joint defects after the resection of malignant tumors remains a major challenge. Chemotherapy has significantly lowered the risk of metastasic disease, but complications associated with reconstructive techniques continue to result in late morbidity. In the present study, biomechanical torsion testing, gait analysis, and histomorphometric and scanning electron microscopic evaluations of 24 dogs were used to examine the effects of preoperative and postoperative administration of cisplatin on the biologic fixation of a porous-coated segmental replacement prosthesis. The chemotherapy consisted of four cycles of cisplatin administered at a dosage of 75 mg/m2 preoperatively or postoperatively. The healing was enhanced by use of an autogenous corticocancellous bone graft. The graft was placed evenly around the prosthesis and the adjacent femoral cortex. Mechanical analyses of torsional stiffness, yield strength, and maximum strength revealed no statistically significant differences between the groups at 12 weeks. Such lack of difference was mainly due to the penetration of highly organized fibrous tissue into the porous surface; this provided strong fixation of the implant to bone even in the absen...Continue Reading

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Citations

May 16, 2002·American Journal of Veterinary Research·Nicole EhrhartAntonio Feretti
Feb 21, 2016·Journal of Cranio-maxillo-facial Surgery : Official Publication of the European Association for Cranio-Maxillo-Facial Surgery·Haytham Al-MahalawyBadr Al-Jandan
Oct 24, 2009·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Peyman HadjiMatthias Kalder
Jul 19, 2005·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Petri VirolainenEdmund Y S Chao
Apr 29, 1999·The Journal of Arthroplasty·H KienapfelP Griss
Aug 5, 2003·Clinical Orthopaedics and Related Research·Barbara L Van LeeuwenHarald J Hoekstra
Aug 15, 2006·Clinical Orthopaedics and Related Research·Sanjeev SharmaCindy Wong
Jun 5, 2007·Clinical Orthopaedics and Related Research·Sanjeev SharmaCindy Wong
Mar 1, 2006·Clinical Orthopaedics and Related Research·Mujahid Jamil KhattakMohammad Umar
Apr 26, 2019·Clinical Oral Implants Research·Marcos Vinícius Mendes DantasMarisa Aparecida Cabrini Gabrielli
Feb 26, 2016·Implant Dentistry·Bruno Ramos ChrcanovicAnn Wennerberg
Oct 31, 2007·Scandinavian Journal of Surgery : SJS : Official Organ for the Finnish Surgical Society and the Scandinavian Surgical Society·P KeränenH T Aro
May 4, 1999·The Journal of Bone and Joint Surgery. American Volume·P VirolainenE Y Chao
Nov 13, 2020·Acta Biomaterialia·Mohammed MahriFaleh Tamimi

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