Effect of citrus-based products on urine profile: A systematic review and meta-analysis

F1000Research
Fakhri RahmanNur Rasyid

Abstract

Background. Urolithiasis is a disease with high recurrence rate, 30-50% within 5 years. The aim of the present study was to learn the effects of citrus-based products on the urine profile in healthy persons and people with urolithiasis compared to control diet and potassium citrate.  Methods. A systematic review was performed, which included interventional, prospective observational and retrospective studies, comparing citrus-based therapy with standard diet therapy, mineral water, or potassium citrate. A literature search was conducted using PUBMED, COCHRANE, and Google Scholar with "citrus or lemonade or orange or grapefruit or lime or juice" and "urolithiasis" as search terms. For statistical analysis, a fixed-effects model was conducted when p > 0.05, and random-effects model was conducted when p < 0.05.  Results. In total, 135 citations were found through database searching with 10 studies found to be consistent with our selection criteria. However, only 8 studies were included in quantitative analysis, due to data availability. The present study showed a higher increased in urine pH for citrus-based products (mean difference, 0.16; 95% CI 0.01-0.32) and urinary citrate (mean difference, 124.49; 95% CI 80.24-168.74) compar...Continue Reading

References

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Citations

Sep 18, 2018·Annals of the New York Academy of Sciences·Shashank GhaiAlfred O Effenberg
Sep 19, 2018·Nephrology·Wattanachai UngjaroenwathanaPiyaratana Tosukhowong

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Methods Mentioned

BETA
urine volume

Software Mentioned

Review Manager ( RevMan )
PUBMED
COCHRANE
EndNote X6
Google Scholar

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