Effect of CLA on milk fat synthesis in dairy cows: comparison of inhibition by methyl esters and free fatty acids, and relationships among studies

Lipids
Michael J de VethDale E Bauman

Abstract

CLA is a potent inhibitor of milk fat synthesis, as shown by investigations using mixtures of CLA isomers in FFA form. However, methyl esters of CLA can be initially formed in commercial synthesis, and their use in a supplement has certain manufacturing and cost advantages. Our objective was to compare abomasal infusion of methyl esters of CLA (ME-CLA) and FFA of CLA (FFA-CLA) on milk fat synthesis. Data were also combined with previous investigations to examine broader relationships between trans-10,cis-12 CLA and the reduction in milk fat. Three mid-lactation, rumen-fistulated Holstein cows were used in a 3 x 3 Latin square design. Treatments were (i) control, (ii) ME-CLA, and (iii) FFA-CLA. The ME-CLA and FFA-CLA treatments (4.2 g/d trans-10,cis-12 CLA) resulted in a comparable reduction in milk fat yield (38 and 39%, respectively) and pattern of reduction in individual FA. In contrast, milk yield, milk protein, and feed intake were unaltered by CLA treatment. Combining data across studies revealed strong correlations relating the reduction in milk fat yield to abomasal dose of trans-10,cis-12 CLA (R2 = 0.86), milk fat content of trans-10,cis-12 CLA (R2 = 0.93), and milk fat secretion of trans-10,cis-12 CLA (R2 = 0.82). Acro...Continue Reading

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Citations

Nov 17, 2007·The British Journal of Nutrition·K J ShingfieldJ M Griinari
Jan 1, 2009·Animal : an International Journal of Animal Bioscience·K J HarvatineD E Bauman
Aug 1, 2010·Animal : an International Journal of Animal Bioscience·R MohammedJ J Murphy
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Mar 24, 2012·Animal : an International Journal of Animal Bioscience·G MaxinF Glasser
Jun 23, 2009·Journal of Lipid Research·Pilar Gómez-CortésMiguel Angel de la Fuente
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May 17, 2011·Annual Review of Nutrition·Dale E BaumanAdam L Lock
Sep 23, 2014·The Veterinary Clinics of North America. Food Animal Practice·Thomas C Jenkins, Kevin J Harvatine
Oct 28, 2015·Journal of Dairy Science·R BodkowskiA Wiliczkiewicz
Nov 23, 2007·Archives of Animal Nutrition·Annabelle Troegeler-MeynadierFrancis Enjalbert
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