Effect of clarithromycin pre-treatment on the pharmacokinetics of metoclopramide after their simultaneous oral intake.

Expert Opinion on Drug Metabolism & Toxicology
Iram KaukabGhulam Murtaza

Abstract

The objective of this study was to assess the influence of enzyme suppression on the values of various pharmacokinetic factors of orally administered metoclopramide. This study was conducted in two phases and a 4-week duration was adopted for drug washout. This randomized study involved 12 healthy human volunteers who received a single oral dose of metoclopramide 20 mg. After the washout period, volunteers received clarithromycin 500 mg two times per day for consecutive 5 days. On test day (fifth day), a single oral dose of metoclopramide 20 mg was also given to the volunteers, and collection of blood samples was conducted at pre-decided time points. Various pharmacokinetic parameters such as Cmax, Tmax, and AUC0-∞ of metoclopramide were determined by analyzing the blood samples using a validated HPLC-UV method. Clarithromycin increased the mean values of Cmax, AUC0-∞, and T1/2 of metoclopramide by 46%, 78.6%, and 9.8%, respectively. Clarithromycin noticeably increased the concentration of plasma metoclopramide. This study's results provide in vivo confirmation of the CYP3A4 involvement in metoclopramide metabolism, in addition to CYP2D6. Therefore, metoclopramide pharmacokinetics may be clinically affected by clarithromycin an...Continue Reading

References

Jan 1, 1992·Critical Reviews in Toxicology·S A Wrighton, J C Stevens
May 1, 1995·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·M ToniniC A Rizzi
Sep 5, 1998·Clinical Pharmacology and Therapeutics·J C GorskiS D Hall
Oct 26, 2001·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·J Kuhlmann, W Mück
Feb 21, 2002·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Zeruesenay DestaD A Flockhart
Oct 27, 2004·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Angela DoranChenghong Zhang
May 16, 2006·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Jinglei YuC Roland Wolf
Jan 17, 2007·British Journal of Clinical Pharmacology·Jari J LiljaPertti J Neuvonen
Jan 15, 2010·Basic & Clinical Pharmacology & Toxicology·José Augusto Guimarães Morais, Maria do Rosário Lobato
Jan 16, 2010·European Journal of Clinical Pharmacology·Teijo I SaariKlaus T Olkkola
Apr 29, 2010·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Upendra A ArgikarSwati Nagar
Jul 20, 2010·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Roberto LeoneAnita Conforti
Sep 10, 2013·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·Mara R LivezeyLaura Lowe Furge

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