Effect of clavulanic acid on minimal inhibitory concentrations of 16 antimicrobial agents tested against Legionella pneumophila.

Antimicrobial Agents and Chemotherapy
D PohlodM M Somerville

Abstract

A total of 15 Legionella pneumophilia isolated were tested against 16 antimicrobial agents used singly and in combination with clavulanic acid. When combined with clavulanic acid, 4 of the 16 antimicrobial agents produced no enhanced effect. However, the minimal inhibitory concentrations of 12 of the antimicrobial agents were reduced by one-half to one-third when in combination with clavulanic acid. These reductions reflected only a one-dilution decrease, however, in the original minimal inhibitory concentrations. Thus, clavulanic acid combinations appear to be only nominally effective beta-lactamase inhibitors against L. pneumophilia.

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Citations

Oct 1, 1984·European Journal of Clinical Microbiology·G RuckdeschelA Ahl
Jan 1, 1994·Antimicrobial Agents and Chemotherapy·L A CollinsG M Eliopoulos
Jan 1, 1996·Biulleten' eksperimental'noĭ biologii i meditsiny·A A KubatievE N Tomilova
Jan 1, 1982·Critical Reviews in Clinical Laboratory Sciences·A C de BoerA G Turpie
Apr 1, 1985·Scandinavian Journal of Clinical and Laboratory Investigation·S SacchiP G Benedetti

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