Abstract
1. The aim of the present study was to explore the contribution of adrenergic, sensory and nitrergic innervations to the inhibitory effects of the beta2-adrenoceptor agonist clenbuterol on responses to electrical field stimulation (EFS, 200 mA, 0.3 ms, 1-16 Hz, for 30 s, at 1 min interval) in rat mesenteric artery segments without endothelium and the possible involvement of adrenergic, sensory and nitrergic innervations. 2. Clenbuterol (1 microM) reduced EFS-induced contractile responses, and this effect was reversed by the beta-antagonist propranolol (1 microM) (contraction at 16 Hz expressed as % of 75 mM K+-induced contraction was: control, 69+/-9, clenbuterol, 31+/-6, n=13, P<0.001; control, 83+/-5, clenbuterol+propranolol 70+/-7, n=11, P>0.05). 3. In arteries preincubated with [3H]-noradrenaline (NA), clenbuterol did not modify the tritium overflow evoked by EFS (200 mA, 0.3 ms, 4 Hz, for 60 s; ratio between tritium release in the second and first stimuli was: control, 0.80+/-0.05 and clenbuterol added before second stimulus, 0.91+/-0.11, n=5, P>0.05). 4. The nitric oxide (NO) synthase inhibitors NG-monomethyl-L-arginine (L-NMMA) and NG-nitro-L-arginine methyl ester (L-NAME) (10 and 100 microM), and the guanylate cyclase i...Continue Reading
References
Jan 7, 1992·European Journal of Pharmacology·Y J Li, S P Duckles
Jul 15, 1992·Biochemical and Biophysical Research Communications·C GonzalezC Estrada
Apr 3, 1991·European Journal of Pharmacology·Y J Li, S P Duckles
May 1, 1991·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·C González, C Estrada
Feb 1, 1990·British Journal of Pharmacology·P K MooreA Gibson
Jul 8, 1985·Brain Research·E J MarcoJ Marín
Apr 1, 1986·Medicinal Research Reviews·Y Misu, T Kubo
Sep 8, 1988·Nature·H KawasakiK Goto
Jun 30, 1988·Biochemical and Biophysical Research Communications·R M PalmerS Moncada
Mar 19, 1971·Brain Research·K C NielsenB Sporrong
Mar 19, 1971·Brain Research·K C Nielsen, C Owman
Nov 1, 1984·Japanese Journal of Pharmacology·T KuboY Misu
Jan 1, 1981·Physiological Reviews·P M VanhoutteR C Webb
Feb 1, 1981·Canadian Journal of Physiology and Pharmacology·C A GruetterL J Ignarro
Aug 5, 1982·Brain Research·S P Duckles, S H Buck
Sep 1, 1983·Journal of Cardiovascular Pharmacology·B WilffertP A van Zwieten
Mar 9, 1981·Brain Research·H DietlA Philippu
Sep 7, 1993·European Journal of Pharmacology·X J YuH W Deng
Nov 1, 1993·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·C EstradaC González
Jan 1, 1995·Advances in Pharmacology·R LeviH M Lander
Oct 1, 1996·Journal of Autonomic Pharmacology·A EncaboG Balfagón
Citations
Mar 23, 2004·European Journal of Pharmacology·Mercedes FerrerGloria Balfagón
Feb 13, 2001·European Journal of Pharmacology·A Ruiz-NuñoA G García
Apr 16, 2003·European Journal of Pharmacology·Mercedes FerrerGloria Balfagón
Jan 19, 2007·Neuroendocrinology·J Blanco-RiveroM Ferrer
Jan 24, 2013·PloS One·Javier Blanco-RiveroGloria Balfagón
Aug 27, 2013·PloS One·Esther SastreJavier Blanco-Rivero
Dec 10, 2013·Journal of Neurosurgery. Spine·Abraham BrownRichard J Zeman
Aug 13, 2004·Journal of Veterinary Pharmacology and Therapeutics·C BelloliG Re
Sep 16, 2010·British Journal of Pharmacology·Javier Blanco-RiveroGloria Balfagón
Dec 15, 2010·Experimental Physiology·Javier Blanco-RiveroGloria Balfagón
Dec 14, 2004·European Journal of Pharmacology·Mercedes FerrerGloria Balfagón
Jun 5, 2004·Regulatory Peptides·Gloria BalfagónVicente Lahera
Feb 7, 2006·Regulatory Peptides·Iván Márquez-RodasGloria Balfagón
May 7, 2005·Nitric Oxide : Biology and Chemistry·M del Carmen MartínMercedes Ferrer
May 11, 2011·Clinical Science·Javier Blanco-RiveroGloria Balfagón
Mar 10, 2009·Clinical Science·Rosa Aras-LópezGloria Balfagón
Oct 18, 2011·Clinical Science·Esther SastreJavier Blanco-Rivero
May 8, 2015·PloS One·Esther SastreGloria Balfagón
Aug 4, 2016·Scientific Reports·Esther SastreJavier Blanco-Rivero
Apr 21, 2004·Journal of Hypertension·Fabiano E XavierGloria Balfagón
Jun 9, 2016·PloS One·Esther SastreGloria Balfagón
Sep 22, 2005·Journal of Vascular Research·Javier Blanco-RiveroMercedes Ferrer
Jul 17, 2015·British Journal of Pharmacology·D B de QueirozG Balfagón
Feb 23, 2013·Journal of Hypertension·Javier Blanco-RiveroGloria Balfagón
Apr 27, 2020·Acta Physiologica·Fabiano E Xavier
Jun 30, 2012·Shock·Esther SastreGloria Balfagón
Jul 23, 2003·British Journal of Pharmacology·Ian D WakefieldSheila M Gardiner
Jan 10, 2017·PloS One·Diva M VillalpandoMercedes Ferrer
Nov 7, 2000·Journal of Cardiovascular Pharmacology·M FerrerG Balfagón
Jun 24, 2015·Journal of Hypertension·Esther SastreJavier Blanco-Rivero
Aug 3, 2000·American Journal of Physiology. Heart and Circulatory Physiology·T J LeeS Sarwinski
Feb 9, 2000·Life Sciences·M FerrerG Balfagón